GzESTY as an optimized cell-based assay for initial steps in GPCR deorphanization
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DOI: 10.1038/s41467-025-59850-8
Abstract: G protein-coupled receptors (GPCRs) are key pharmacological targets, yet many remain underutilized due to unknown activation mechanisms and ligands. Orphan GPCRs, lacking identified natural ligands, are a high priority for research, as identifying their ligands… read more here.
Keywords: based assay; cell based; activation; deorphanization ... See more keywords
Constitutive G protein coupling profiles of understudied orphan GPCRs
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DOI: 10.1371/journal.pone.0247743
Abstract: A large number of GPCRs are potentially valuable drug targets but remain understudied. Many of these lack well-validated activating ligands and are considered “orphan” receptors, and G protein coupling profiles have not been defined for… read more here.
Keywords: protein; coupling profiles; orphan gpcrs; understudied orphan ... See more keywords