Opportunities and challenges in targeting orphan nuclear receptors.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00954h
Abstract: Nuclear receptor modulation enables pharmacological control of gene expression thus rendering the 48 human nuclear receptors as attractive targets for drug discovery. Several nuclear receptor ligands like glucocorticoids are approved and highly important drugs illustrating… read more here.
Keywords: nuclear receptors; nuclear receptor; challenges targeting; orphan nuclear ... See more keywords
A novel lncRNA NR4A1AS upregulates orphan nuclear receptor NR4A1 expression by blocking UPF1-mediated mRNA destabilization in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical science"
DOI: 10.1042/cs20181061
Abstract: Long non-coding RNAs (lncRNAs) play important roles in tumorigenesis and cancer progression. The orphan nuclear receptor NR4A1 acts as an oncogene, and is involved in colorectal cancer (CRC) development. However, the mechanism through which lncRNA… read more here.
Keywords: expression; cancer; crc; nr4a1 expression ... See more keywords
An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRγ
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1145
Abstract: 1Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, 500–757, Republic of Korea, 2Section of Endocrinology, Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Taegu,… read more here.
Keywords: medicine; national university; orphan nuclear; nuclear receptor ... See more keywords
The orphan nuclear receptor TR4 regulates erythroid cell proliferation and maturation.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-05-783159
Abstract: The orphan nuclear receptors TR4 (NR2C2) and TR2 (NR2C1) are the DNA-binding subunits of the macromolecular complex, direct repeat erythroid-definitive, which has been shown to repress ε- and γ-globin transcription during adult definitive erythropoiesis. Previous… read more here.
Keywords: erythroid differentiation; proliferation; tr4; nuclear receptor ... See more keywords
Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.587457
Abstract: Orphan nuclear receptors are important members of the nuclear receptor family and may regulate cell proliferation, metabolism, differentiation, and apoptosis. NR4As, a subfamily of orphan nuclear receptors, have been reported to play key roles in… read more here.
Keywords: nuclear receptors; homeostasis diabetes; energy; energy homeostasis ... See more keywords
Flavone and Hydroxyflavones Are Ligands That Bind the Orphan Nuclear Receptor 4A1 (NR4A1)
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098152
Abstract: It was recently reported that the hydroxyflavones quercetin and kaempferol bind the orphan nuclear receptor 4A1 (NR4A1, Nur77) and act as antagonists in cancer cells and tumors, and they inhibit pro-oncogenic NR4A1-regulated genes and pathways.… read more here.
Keywords: receptor 4a1; nuclear receptor; bind orphan; orphan nuclear ... See more keywords
Broussochalcone A Is a Novel Inhibitor of the Orphan Nuclear Receptor NR4A1 and Induces Apoptosis in Pancreatic Cancer Cells
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26082316
Abstract: The orphan nuclear receptor 4A1 (NR4A1) is overexpressed in pancreatic cancer and exhibits pro-oncogenic activity, and NR4A1 silencing and treatment with its inactivators has been shown to inhibit pancreatic cancer cells and tumor growth. In… read more here.
Keywords: pancreatic cancer; nuclear receptor; cancer cells; cancer ... See more keywords