The orphan G protein‐coupled receptor GPR149 is a negative regulator of myelination and remyelination
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24233
Abstract: Myelin sheath, formed by oligodendrocytes (OLs) in the central nervous system (CNS) and Schwann cells in periphery, plays a critical role in supporting neuronal functions. OLs, differentiated from oligodendrocyte precursor cells (OPCs), are important for… read more here.
Keywords: orphan protein; remyelination; gpr149; myelination ... See more keywords
Primary cilia, AKAPs and constitutive activity at the orphan G protein-coupled receptor GPR161: a tale about a tail.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16053
Abstract: Primary cilia are non-motile antennae-like structures responsible for sensing environmental changes in most mammalian cells. Ciliary signalling is largely mediated by the Sonic Hedgehog (Shh) pathway, which acts as a master regulator of ciliary protein… read more here.
Keywords: orphan protein; receptor; protein coupled; gpr161 ... See more keywords
Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells.
Sign Up to like & getrecommendations! Published in 2017 at "Endocrine journal"
DOI: 10.1507/endocrj.ej16-0338
Abstract: Pancreatic islets express high levels of the orphan G-protein coupled receptor C5C (GPRC5C), the function of which remains to be established. Here we have examined the role of GPRC5C in the regulation of insulin secretion… read more here.
Keywords: orphan protein; gprc5c; protein coupled; expression ... See more keywords