Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.08.068
Abstract: SUMMARY Establishing synaptic contacts between neurons is paramount for nervous system function. This process involves transsynaptic interactions between a host of cell adhesion molecules that act in cooperation with the proteins of the extracellular matrix… read more here.
Keywords: binding orphan; receptor gpr179; gpr179 dystroglycan; orphan receptor ... See more keywords
Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00572
Abstract: Although G protein-coupled receptors (GPCRs) are recognized as pivotal drug targets involved in multiple physiological and pathological processes, the majority of GPCRs including orphan GPCRs (oGPCRs) are unexploited. GPR88, a brain-specific oGPCR with particularly robust… read more here.
Keywords: gpr88; orphan receptor; target; neurotherapeutic target ... See more keywords
A self-activating orphan receptor
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/d41586-020-00411-y
Abstract: The first 3D structure of a full-length G-protein-coupled receptor whose natural activator is unknown has been determined, providing insights into an unusual mode of activation and a basis for discovering therapeutics. The structure of an… read more here.
Keywords: receptor; self activating; activating orphan; orphan receptor ... See more keywords
RAR-Related Orphan Receptor: An Accelerated Preeclampsia Progression by Activating the JAK/STAT3 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Yonsei Medical Journal"
DOI: 10.3349/ymj.2022.63.6.554
Abstract: Purpose To investigate the effect and underlying mechanism of RAR related orphan receptor A (RORA) on preeclampsia (PE). Materials and Methods Differentially expressed genes (DEGs) in four datasets were obtained by using the Venn diagram… read more here.
Keywords: proliferation; stat3; related orphan; rar related ... See more keywords
Comprehensive insights into the function and molecular and pharmacological regulation of neuron-derived orphan receptor 1, an orphan receptor
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.981490
Abstract: Neuron-derived orphan receptor 1 (NOR1), also called nuclear receptor subfamily 4 group A member 3 (NR4A3), is a nuclear receptor belonging to the NR4A family. Since no endogenous ligand has been identified to date, NOR1… read more here.
Keywords: function; neuron derived; nor1; regulation ... See more keywords
Novel Therapeutic Potential of Retinoid-Related Orphan Receptor α in Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043462
Abstract: The retinoid-related orphan receptor α (RORα) is one subfamily of nuclear hormone receptors (NRs). This review summarizes the understanding and potential effects of RORα in the cardiovascular system and then analyzes current advances, limitations and… read more here.
Keywords: ror; retinoid related; cardiovascular diseases; related orphan ... See more keywords