Manganese‐Catalyzed ortho‐Alkenylation of Aromatic Amidines with Alkynes via C−H Activation
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DOI: 10.1002/cctc.201900387
Abstract: The first ortho‐alkenylation of aromatic amidines with alkynes was realized by earth‐abundant manganese catalysis through C−H activation. A catalytic amount of PhMgBr was found essential for improved efficiency of this transformation. Wide tolerance of functional… read more here.
Keywords: aromatic amidines; ortho alkenylation; amidines alkynes; activation ... See more keywords
Modular Synthesis of 9,10-Dihydroacridines through an ortho-C Alkenylation/Hydroarylation Sequence between Anilines and Aryl Alkynes in Hexafluoroisopropanol.
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DOI: 10.1021/acs.orglett.1c00487
Abstract: 9,10-Dihydroacridines are frequently encountered as key scaffolds in OLEDs. However, accessing those compounds from feedstock precursors typically requires multiple steps. Herein, a modular one-pot synthesis of 9,10-dihydroacridine frameworks is achieved through a reaction sequence featuring… read more here.
Keywords: hydroarylation; ortho alkenylation; aryl alkynes; sequence ... See more keywords
Rhenium-Catalyzed Regioselective ortho-Alkenylation and [3 + 2 + 1] Cycloaddition of Phenols with Internal Alkynes.
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DOI: 10.1021/acs.orglett.9b01214
Abstract: An operationally simple and direct rhenium-catalyzed ortho-alkenylation ( C-alkenylation) of unprotected phenols with alkynes was developed. The protocol provided ortho-alkenylphenols exclusively, and formation of para- or multiply alkenylated phenols and hydrophenoxylation ( O-alkenylation) products were… read more here.
Keywords: ortho alkenylation; cycloaddition phenols; rhenium catalyzed; catalyzed regioselective ... See more keywords
Late-stage ortho-C–H alkenylation of 2-arylindazoles in aqueous medium by Manganese(i)-catalysis
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DOI: 10.1039/d2ra03547b
Abstract: Earth-abundant and water-tolerant manganese(i) catalyzed alkenylation of 2-arylindazole with alkyl and aryl alkynes through C–H bond activation is described with a unique level of E-selectivity. The reaction proceeds through the control of C3 nucleophilicity of… read more here.
Keywords: alkenylation arylindazoles; stage ortho; ortho alkenylation; alkenylation ... See more keywords