Oxidative cyclization of 5-aryl-1-benzyl-1,2,3-triazoles bearing electron-rich aromatic groups: ortho/ortho and ortho/ipso coupling
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DOI: 10.1007/s10593-021-02985-5
Abstract: The intramolecular oxidative coupling of electron-rich aromatic groups in 5-(het)aryl-1-(het)arylalkyl-1H-1,2,3-triazoles was studied in detail. Under treatment with phenyliodoso bis(trifluoroacetate) and boron trifluoride etherate these substrates afforded products of either ortho/ortho or ortho/ipso coupling depending on… read more here.
Keywords: electron rich; ortho ortho; ortho; aromatic groups ... See more keywords
Sequential ortho-C-H and ipso-C-O Functionalization Using a Bifunctional Directing Group.
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DOI: 10.1021/acs.orglett.9b02910
Abstract: Design of C-H activation directing groups that can serve as electrophiles for subsequent cross-coupling significantly improves the step economy of synthetic applications of directed C-H functionalization. Through using a well-defined bifunctional template, palladium-catalyzed ortho-C-H alkenylation… read more here.
Keywords: functionalization using; using bifunctional; sequential ortho; ipso functionalization ... See more keywords
Ortho/Ipso Alkylborylation of Aryl Iodides.
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DOI: 10.1021/acs.orglett.9b03674
Abstract: This work describes a method for the difunctionalization of aryl iodides to generate polysubstituted arenes via Pd catalysis. The reaction hinges on the unique interplay between norbornene and the metal catalyst to impart a guided… read more here.
Keywords: aryl iodides; ipso alkylborylation; alkylborylation aryl; aryl ... See more keywords
A Fast Track to Indoles and Annulated Indoles through ortho- vs ipso-Amination of Aryl Halides.
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DOI: 10.1021/acs.orglett.9b04202
Abstract: A complementary site selective ortho- vs ipso-amination of aryl halides using non-electrophilic amine sources for construction of indole scaffolds is reported. A palladium-catalyzed alkyne insertion/C-H activation/palladacycle amination via merger of three easily diversified components including… read more here.
Keywords: ipso amination; amination; aryl halides; amination aryl ... See more keywords