LAUSR

Diversity-Oriented Synthesis of Glycosylphosphatidylinositol Probes Based on an Orthogonally Protected Pentasaccharide.

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2 Published in 2023 at "Organic letters"

DOI: 10.1021/acs.orglett.3c00448

Abstract: Two glycosylphosphatidylinositol (GPI) derivatives having an alkynyl group at different positions were derived from the same orthogonally protected pentasaccharide that in turn was assembled by a convergent [3+2] glycosylation strategy. The resultant alkynylated GPIs are… read more here.

Keywords: synthesis glycosylphosphatidylinositol; orthogonally protected; oriented synthesis; diversity oriented ... See more keywords

Orthogonally Protected Diaminocyclopentenones as Synthons: Total Synthesis of (±)-Agelastatin A.

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2 Published in 2023 at "Organic letters"

DOI: 10.1021/acs.orglett.3c01513

Abstract: Natural products containing aminocyclopentanes are common secondary metabolites, often biologically active. This work aims at the preparation of a useful synthon for total synthesis containing orthogonally protected amines. To this end, furfural and two amines… read more here.

Keywords: protected diaminocyclopentenones; orthogonally protected; synthesis; diaminocyclopentenones synthons ... See more keywords

Scalable Synthesis of Orthogonally Protected β-Methyllanthionines by Indium(III)-Mediated Ring Opening of Aziridines.

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0 Published in 2019 at "Organic letters"

DOI: 10.1021/acs.orglett.9b00125

Abstract: Lantibiotics are a class of peptide antibiotics with activity against most Gram-positive bacteria. Lanthionine (Lan) and β-MeLan are unusual thioether-bridged, non-proteinogenic amino acids, which are characteristic features of lantibiotics. In this paper, we report the… read more here.

Keywords: ring opening; synthesis orthogonally; orthogonally protected; scalable synthesis ... See more keywords

Synthesis of Four Orthogonally Protected Rare l-Hexose Thioglycosides from d-Mannose by C-5 and C-4 Epimerization

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1 Published in 2022 at "Molecules"

DOI: 10.3390/molecules27113422

Abstract: l-Hexoses are important components of biologically relevant compounds and precursors of some therapeuticals. However, they typically cannot be obtained from natural sources and due to the complexity of their synthesis, their commercially available derivatives are… read more here.

Keywords: rare hexose; orthogonally protected; hexose thioglycosides; protected rare ... See more keywords