DCPP1 is the mouse ortholog of human PAUF that possesses functional analogy in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.015
Abstract: Pancreatic adenocarcinoma upregulated factor (PAUF) overexpressed in pancreatic ductal adenocarcinoma (PDAC) plays a major role in tumor progression and metastasis by autocrine and paracrine manners. However, underlying molecular mechanism of PAUF functioning in pancreatic cancer… read more here.
Keywords: ortholog human; human pauf; pancreatic cancer; cancer ... See more keywords
Identification of zebrafish ortholog for human coagulation factor IX and its age‐dependent expression
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15365
Abstract: Coagulation factor IX (FIX) is a serine protease zymogen involved in the intrinsic blood coagulation pathway, and its deficiency causes hemophilia B. Zebrafish has three f9 genes, and the ortholog to human F9 is unknown. read more here.
Keywords: identification zebrafish; coagulation; coagulation factor; ortholog human ... See more keywords
Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD.
Sign Up to like & getrecommendations! Published in 2018 at "JCI insight"
DOI: 10.1172/jci.insight.95874
Abstract: Autosomal dominant polycystic kidney disease (ADPKD) can be caused by mutations in the PKD1 or PKD2 genes. The PKD1 gene product is a Wnt cell-surface receptor. We previously showed that a lack of the PKD2… read more here.
Keywords: wnt; catenin signaling; mouse ortholog; catenin ... See more keywords
The Crystal Structure of Mouse Ces2c, a Potential Ortholog of Human CES2, Shows Structural Similarities in Substrate Regulation and Product Release to Human CES1
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113101
Abstract: Members of the carboxylesterase 2 (Ces2/CES2) family have been studied intensively with respect to their hydrolytic function on (pro)drugs, whereas their physiological role in lipid and energy metabolism has been realized only within the last… read more here.
Keywords: ortholog human; human ces2; structure; potential ortholog ... See more keywords