In Silico Clinical Trials in the Orthopedic Device Industry: From Fantasy to Reality?
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-021-02787-y
Abstract: The orthopedic device industry relies heavily on clinical evaluation to confirm the safety, performance, and clinical benefits of its implants. Limited sample size often prevents these studies from capturing the full spectrum of patient variability… read more here.
Keywords: orthopedic device; clinical trials; silico clinical; device industry ... See more keywords
Role of Rifampin against Staphylococcal Biofilm Infections In Vitro, in Animal Models, and in Orthopedic-Device-Related Infections
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DOI: 10.1128/aac.01746-18
Abstract: Rifampin has been used as an agent in combination therapy in orthopedic device-related infections (ODRI) for almost three decades. The aim of this review is to provide data regarding the role of rifampin against biofilm… read more here.
Keywords: device related; orthopedic device; role rifampin; related infections ... See more keywords
Comparative Genomics Study of Staphylococcus epidermidis Isolates from Orthopedic-Device-Related Infections Correlated with Patient Outcome
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DOI: 10.1128/jcm.00881-17
Abstract: ABSTRACT Staphylococcus epidermidis has emerged as an important opportunistic pathogen causing orthopedic-device-related infections (ODRI). This study investigated the association of genome variation and phenotypic features of the infecting S. epidermidis isolate with the clinical outcome… read more here.
Keywords: device related; outcome; orthopedic device; epidermidis ... See more keywords
Clinical Metagenomic Sequencing for Species Identification and Antimicrobial Resistance Prediction in Orthopedic Device Infection
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DOI: 10.1128/jcm.02156-21
Abstract: Diagnosis of orthopedic device-related infection is challenging, and causative pathogens may be difficult to culture. Metagenomic sequencing can diagnose infections without culture, but attempts to detect antimicrobial resistance (AMR) determinants using metagenomic data have been… read more here.
Keywords: culture; orthopedic device; infection; metagenomic sequencing ... See more keywords
Trends in Orthopedic Device Innovation: An Analysis of 510(k) Clearances and Premarket Approvals From 2000 to 2019.
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DOI: 10.3928/01477447-20221129-06
Abstract: The objective of this study was to characterize recent trends in orthopedic device development across different subspecialty areas. Orthopedic 510(k) clearances, premarket approvals (PMAs; together, "authorizations"), and new market entrants from 2000 to 2019 were… read more here.
Keywords: 2000 2019; 510 clearances; clearances premarket; trends orthopedic ... See more keywords