Bone infection site targeting nanoparticle-antibiotics delivery vehicle to enhance treatment efficacy of orthopedic implant related infection
Sign Up to like & getrecommendations! Published in 2022 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2022.02.003
Abstract: Orthopedic implants account for 99% of orthopedic surgeries, however, orthopedic implant-related infection is one of the most serious complications owing to the potential for limb-threatening sequelae and mortality. Current antibiotic treatments still lack the capacity… read more here.
Keywords: bone infection; infection; implant related; related infection ... See more keywords
Development of PLA/Mg composite for orthopedic implant: Tunable degradation and enhanced mineralization
Sign Up to like & getrecommendations! Published in 2017 at "Composites Science and Technology"
DOI: 10.1016/j.compscitech.2017.04.037
Abstract: Abstract Polylactic acid (PLA) orthopedic devices suffer from low degradation rate and inadequate osteoconductivity, and often lose efficacy in the late stage of implantation because of inflammatory response of acid products and inability integration to… read more here.
Keywords: pla composite; degradation; pla; development pla ... See more keywords
Chitosan nanoparticles and povidone iodine containing alginate gel for prevention and treatment of orthopedic implant associated infections.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.04.166
Abstract: Orthopedic Implant associated infections (OIAIs) are the most serious complications in the orthopedic surgery. Such complications are of major concern unless encountered during initial stages of contamination due to the bacterial biofilm formation. Thus, our… read more here.
Keywords: alginate; alg gel; cnps alg; gel ... See more keywords
Are conventional microbiological diagnostics sufficiently expedient in the era of rapid diagnostics? Evaluation of conventional microbiological diagnostics of orthopedic implant-associated infections (OIAI)
Sign Up to like & getrecommendations! Published in 2020 at "Acta Orthopaedica"
DOI: 10.1080/17453674.2020.1844499
Abstract: Background and purpose — In a time when rapid diagnostics are increasingly sought, conventional procedures for detection of microbes causing orthopedic implant-associated infections (OIAI) seem extensive and time-consuming, but how extensive are they? We assessed… read more here.
Keywords: treatment; microbiological diagnostics; conventional microbiological; time ... See more keywords
Bactericide hydrogel prevents orthopedic implant infections
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aau0463
Abstract: A hydrogel formulation adheres to exposed tissue and fracture surfaces to deliver antimicrobial enzymes for localized treatment and prevention of orthopedic implant infections. A hydrogel formulation adheres to exposed tissue and fracture surfaces to deliver… read more here.
Keywords: bactericide hydrogel; hydrogel prevents; implant infections; orthopedic implant ... See more keywords
Safety and Efficacy of Prolonged Use of Dalbavancin in Bone and Joint Infections
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02280-18
Abstract: Dalbavancin is a lipoglycopeptide with potent activity against Gram-positive microorganisms, a long half-life, a favorable safety profile, and a high concentration in bone, which makes it an interesting alternative for treatment of osteoarticular infections. We… read more here.
Keywords: dalbavancin; infection; safety efficacy; bone ... See more keywords
Novel Bioactive Magnesium-Hopeite composite by friction stir processing for orthopedic implant applications
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine"
DOI: 10.1177/09544119231158837
Abstract: Graphical abstract Magnesium (Mg) shows excellent potential for orthopedic implant applications owing to its equivalent mechanical properties compared to cortical bone and its biocompatibility. However, the rapid degradation rate of magnesium and its alloys in… read more here.
Keywords: magnesium; hopeite; orthopedic implant; hopeite composite ... See more keywords
Mg-, Zn-, and Fe-Based Alloys With Antibacterial Properties as Orthopedic Implant Materials
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.888084
Abstract: Implant-associated infection (IAI) is one of the major challenges in orthopedic surgery. The development of implants with inherent antibacterial properties is an effective strategy to resolve this issue. In recent years, biodegradable alloy materials have… read more here.
Keywords: orthopedic implant; based alloys; alloys antibacterial; implant materials ... See more keywords
Chemokines Associated with Pathologic Responses to Orthopedic Implant Debris
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2017.00005
Abstract: Despite the success in returning people to health saving mobility and high quality of life, the over 1 million total joint replacements implanted in the US each year are expected to eventually fail after approximately 15–25 years… read more here.
Keywords: innate; chemokines associated; associated pathologic; implant debris ... See more keywords
Biofilm formation and inflammatory potential of Staphylococcus saccharolyticus: A possible cause of orthopedic implant-associated infections
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1070201
Abstract: Staphylococcus saccharolyticus, a coagulase-negative staphylococcal species, has some unusual characteristics for human-associated staphylococci, such as slow growth and its preference for anoxic culture conditions. This species is a relatively abundant member of the human skin… read more here.
Keywords: implant associated; associated infections; orthopedic implant; saccharolyticus ... See more keywords
Amplicon-Based Next-Generation Sequencing as a Diagnostic Tool for the Detection of Phylotypes of Cutibacterium acnes in Orthopedic Implant-Associated Infections
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.866893
Abstract: The diagnosis of orthopedic implant-associated infections (OIAIs) caused by the slow-growing anaerobic bacterium Cutibacterium acnes is challenging. The mild clinical presentations of this low-virulent bacterium along with its ubiquitous presence on human skin and human-dominated… read more here.
Keywords: culture; type; orthopedic implant; associated infections ... See more keywords