Development of VU6019650: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M5 Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder.
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DOI: 10.1021/acs.jmedchem.2c00192
Abstract: The muscarinic acetylcholine receptor (mAChR) subtype 5 (M5) represents a novel potential target for the treatment of multiple addictive disorders, including opioid use disorder. Through chemical optimization of several functional high-throughput screening hits, VU6019650 (27b)… read more here.
Keywords: orthosteric antagonist; acetylcholine receptor; opioid use; use disorder ... See more keywords