Imaging acute effects of bevacizumab on tumor vascular kinetics in a preclinical orthotopic model of U251 glioma
Sign Up to like & getrecommendations! Published in 2021 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4516
Abstract: The effect of a human vascular endothelial growth factor antibody on the vasculature of human tumor grown in rat brain was studied. Using dynamic contrastâenhanced magnetic resonance imaging, the effects of intravenous bevacizumab (Avastin; 10… read more here.
Keywords: tumor vascular; orthotopic; time; vascular kinetics ... See more keywords
NIR-II Perylene Monoimide-Based Photothermal Agent with Strengthened Donor-Acceptor Conjugation for Deep Orthotopic Glioblastoma Phototheranostics.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202300203
Abstract: Extensive efforts have been devoted to the design of organic photothermal agents (PTAs) that absorb in the second near-infrared (NIR-II) bio-window, which can provide deeper tissue penetration that is significant for phototheranostics of lethal brain… read more here.
Keywords: orthotopic; orthotopic glioblastoma; deep orthotopic; agent ... See more keywords
Orthotopic ureterocele with concurrent ureteral urothelial carcinoma in a dog
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.884
Abstract: Abstract A ureterocele is a rare congenital anomaly with cystic dilation of the terminal segment of the ureter entirely within the bladder (orthotopic) or associated with ectopic ureter (ectopic). Its aetiology has not been fully… read more here.
Keywords: orthotopic; orthotopic ureterocele; urothelial carcinoma; dog orthotopic ... See more keywords
Temozolomide combined with PD-1 Antibody therapy for mouse orthotopic glioma model.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.064
Abstract: PURPOSE Temozolomide (TMZ) is the most frequent adjuvant chemotherapy drug in gliomas. PDL1 expresses on various tumors, including gliomas, and anti-PD-1 antibodies have been approved for treating some tumors by FDA. This study was to… read more here.
Keywords: glioma; orthotopic; antibody; group ... See more keywords
Nano-Codelivery of Temozolomide and siPD-L1 to Reprogram the Drug-Resistant and Immunosuppressive Microenvironment in Orthotopic Glioblastoma.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c09794
Abstract: Glioblastoma (GBM) is an invasive cancer with high mortality in central nervous system. Resistance to temozolomide (TMZ) and immunosuppressive microenvironment lead to low outcome of the standardized treatment for GBM. In this study, a 2-deoxy-d-glucose… read more here.
Keywords: orthotopic; tmz resistant; tmz sipd; resistant gbm ... See more keywords
NIR-II Light Leveraged Dual Drug Synthesis for Orthotopic Combination Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c06314
Abstract: Pd-catalyzed bioorthogonal bond cleavage reactions are widely used and frequently reported. It is circumscribed by low reaction efficiency, which may encumber the therapeutic outcome when applied to physiological environments. Herein, an NIR-II light promoted integrated… read more here.
Keywords: reaction; orthotopic; combination therapy; nir light ... See more keywords
Controlling Disassembly of Paramagnetic Prodrug and Photosensitizer Nanoassemblies for On-Demand Orthotopic Glioma Theranostics.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c07491
Abstract: Controlling delivery and release of therapeutic agents to accomplish on-demand synergistic therapy of orthotopic gliomas is desired but challenging. Here, we report a glioma targeting and redox activatable theranostic nanoprobe (Co-NP-RGD1/1) for magnetic resonance (MR)… read more here.
Keywords: orthotopic; controlling disassembly; disassembly paramagnetic; photosensitizer ... See more keywords
Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73150-9
Abstract: Xenotransplantation using pig organs has achieved survival times up to 195 days in pig orthotopic heart transplantation into baboons. Here we demonstrate that in addition to an improved immunosuppressive regimen, non-ischaemic preservation with continuous perfusion… read more here.
Keywords: impact porcine; orthotopic; cytomegalovirus; cytomegalovirus long ... See more keywords
Comparative performance of the different orthotopic urinary diversions
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Urology"
DOI: 10.1097/mou.0000000000001016
Abstract: Purpose of review Majority of patients undergoing radical cystectomy are suitable for orthotopic urinary diversion. The effect of different techniques of neobladder reconstruction on early and long-term postoperative complications is still being determined. Additionally, it… read more here.
Keywords: long term; orthotopic; different orthotopic; orthotopic urinary ... See more keywords
Abstract 89: Development and characterization of a panel of orthotopic glioblastoma multiforme (GBM) patient-derived xenograft (PDX) mouse models for drug efficacy evaluation
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-89
Abstract: Background Glioblastoma multiforme (GBM) is an aggressive cancer type with poor prognosis and survival. The lack of effective treatment may be due to the complex molecular composition and the heterogeneity of the tumors. Subcutaneous patient… read more here.
Keywords: panel; development; pdx mouse; pdx ... See more keywords
Abstract 3537: A novel orthotopic xenograft model of spontaneous metastasis for rhabdomyosarcoma using lingual intramuscular injection
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3537
Abstract: Rhabdomyosarcoma (RMS), a cancer characterized by the defective differentiation of skeletal muscle precursor cells, is the most common pediatric soft tissue sarcoma. Despite significant efforts to characterize the transcriptomic and genetic abnormalities of the disease,… read more here.
Keywords: injection; xenograft model; orthotopic; metastasis ... See more keywords