Synthesis, biochemical, pharmacological characterization and in silico profile modelling of highly potent opioid orvinol and thevinol derivatives.
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DOI: 10.1016/j.ejmech.2020.112145
Abstract: Morphine and its derivatives play inevitably important role in the μ-opioid receptor (MOR) targeted antinociception. A structure-activity relationship study is presented for novel and known orvinol and thevinol derivatives with varying 3-O, 6-O, 17-N and… read more here.
Keywords: orvinol thevinol; synthesis biochemical; thevinol derivatives; biochemical pharmacological ... See more keywords