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   Articles with "oscc cells" as a keyword



Semaglutide, a glucagon-like peptide-1 receptor agonist, inhibits oral squamous cell carcinoma growth through P38 MAPK signaling pathway

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recommendations! Published in 2025 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-025-06154-5

Abstract: Researches have shown that diabetes mellitus (DM) can promote the risk and progression of oral squamous cell carcinoma (OSCC). Semaglutide, a glucagon-like peptide-1 receptor agonist, is currently employed to treat type 2 diabetes mellitus (T2DM)… read more here.

Keywords: oscc cells; mapk signaling; p38 mapk; cell ... See more keywords

Anti-EGFR antibody cetuximab is secreted by oral squamous cell carcinoma and alters EGF-driven mesenchymal transition.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.07.035

Abstract: Genetic amplification, overexpression, and increased signaling from the epidermal growth factor receptor (EGFR) are often found in oral squamous cell carcinoma (OSCC) and thus EGFR is frequently targeted molecularly by the therapeutic antibody cetuximab. We… read more here.

Keywords: egf driven; egfr; oral squamous; oscc cells ... See more keywords

Differentiated embryo-chondrocyte 1, induced by hypoxia-inducible factor 1α, promotes cell migration in oral squamous cell carcinoma cell lines.

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recommendations! Published in 2021 at "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"

DOI: 10.1016/j.oooo.2021.08.022

Abstract: Abstract Objective This study aimed to explore the correlation between differentiated embryo chondrocyte 1 (DEC1) and hypoxia-inducible factor 1α (HIF-1α) in OSCC and how they participate in tumor progression. Study Design An immunohistochemical staining method… read more here.

Keywords: oscc cells; dec1; hypoxia; cell ... See more keywords

Ubiquitin-specific protease 14 promotes radio-resistance and suppresses autophagy in oral squamous cell carcinoma.

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recommendations! Published in 2020 at "Experimental cell research"

DOI: 10.1016/j.yexcr.2020.112385

Abstract: Oral squamous cell carcinoma (OSCC) is a common malignant tumor in the world. Radiotherapy is one of the standard therapies for patients with OSCC, but its clinical efficiency is limited due to radioresistance. In this… read more here.

Keywords: usp14 expression; oscc cells; usp14 knockdown; cell ... See more keywords

Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition

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recommendations! Published in 2025 at "Cell Death Discovery"

DOI: 10.1038/s41420-025-02314-1

Abstract: Emerging evidence shows that lipid metabolic reprogramming plays a vital role in tumor metastasis. The effect and mechanism of fatty acids and lipid droplets (LDs), the core products of lipid metabolism, on the metastasis of… read more here.

Keywords: plin2; metastasis oral; oscc cells; lipid droplets ... See more keywords

The inhibitory effect in oral squamous cell carcinoma cells by knocking down matrix metalloproteinase 9

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recommendations! Published in 2019 at "Annals of Oncology"

DOI: 10.1093/annonc/mdz238.018

Abstract: Abstract Background Extracellular matrix (ECM) is a basic step of tumor invasion and metastasis. Matrix metalloproteinase (MMPs) family is a kind of zinc-ion-dependent endopeptidase, which can degrade almost all protein components in the extracellular matrix,… read more here.

Keywords: invasion; cell carcinoma; oral squamous; squamous cell ... See more keywords

HOXA1 silencing inhibits cisplatin resistance of oral squamous cell carcinoma cells via IκB/NF-κB signaling pathway

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recommendations! Published in 2024 at "Anti-Cancer Drugs"

DOI: 10.1097/cad.0000000000001592

Abstract: The resistance of oral squamous cell carcinoma (OSCC) cells to cisplatin remains a tough nut to crack in OSCC therapy. Homeobox A1 (HOXA1) overexpression has been detected in head and neck squamous carcinoma (HNSC). Accordingly,… read more here.

Keywords: resistance; cisplatin; hoxa1 silencing; oscc cells ... See more keywords

Spindly and Bub3 expression in oral cancer: Prognostic and therapeutic implications.

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recommendations! Published in 2019 at "Oral diseases"

DOI: 10.1111/odi.13089

Abstract: OBJECTIVES Bub3 and Spindly are essential proteins required for the activation and inactivation of the spindle assembly checkpoint, respectively. Here, we explored the clinicopathological significance and the therapeutic potential of the opposing roles of the… read more here.

Keywords: spindly bub3; bub3 spindly; oscc cells; expression ... See more keywords

Upregulated circ_0002141 facilitates oral squamous cell carcinoma progression via the miR-1231/EGFR axis.

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recommendations! Published in 2021 at "Oral diseases"

DOI: 10.1111/odi.14070

Abstract: OBJECTIVES The dysregulation of circular RNAs (circRNAs) is implicated in the progression of various cancers. This study was aimed at expounding the role and mechanism of hsa_circ_0002141 in the OSCC progression. MATERIALS AND METHODS Circ_0002141… read more here.

Keywords: oscc cells; mir 1231; progression; circ 0002141 ... See more keywords

PDZ-binding kinase inhibitor OTS514 suppresses the proliferation of oral squamous carcinoma cells.

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recommendations! Published in 2023 at "Oral diseases"

DOI: 10.1111/odi.14533

Abstract: OBJECTIVE PDZ-binding kinase (PBK) has been reported as a poor prognostic factor and is a promising molecular target for anti-cancer therapeutics. Here, we aimed to investigate the effect of specific PBK inhibitor OTS514 on the… read more here.

Keywords: oscc cells; pdz binding; ots514; inhibitor ots514 ... See more keywords

MRTF-A/SRF signaling suppresses invasion of oral squamous cell carcinoma.

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recommendations! Published in 2023 at "Oral diseases"

DOI: 10.1111/odi.14611

Abstract: BACKGROUND Serum response factor (SRF) and myocardial-associated transcription factor-A (MRTF-A) had different regulatory effects on the tumorigenesis and development in different cancers. However, the role of MRTF-A/SRF in oral squamous cell carcinoma (OSCC) remains to… read more here.

Keywords: oscc cells; cell; srf; mrtf srf ... See more keywords