Association of Early Oseltamivir With Improved Outcomes in Hospitalized Children With Influenza, 2007-2020.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2022.3261
Abstract: Importance Oseltamivir is recommended for all children hospitalized with influenza, despite limited evidence supporting its use in the inpatient setting. Objective To determine whether early oseltamivir use is associated with improved outcomes in children hospitalized… read more here.
Keywords: day; oseltamivir; hospitalized influenza; early oseltamivir ... See more keywords
Comparison of anti-influenza virus activity and pharmacokinetics of oseltamivir free base and oseltamivir phosphate
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Microbiology"
DOI: 10.1007/s12275-017-7371-x
Abstract: Influenza viruses are major human respiratory pathogens that cause high morbidity and mortality worldwide. Currently, prophylactic vaccines and therapeutic antiviral agents are used to prevent and control influenza virus infection. Oseltamivir free base (OSV-FB), a… read more here.
Keywords: oseltamivir; free base; influenza virus; virus ... See more keywords
Host-targeted Nitazoxanide has a high barrier to resistance but does not reduce the emergence or proliferation of oseltamivir-resistant influenza viruses in vitro or in vivo when used in combination with oseltamivir.
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral research"
DOI: 10.1016/j.antiviral.2020.104851
Abstract: A major limitation of the currently available influenza antivirals is the potential development of drug resistance. The adamantanes, neuraminidase inhibitors, and more recently polymerase inhibitors, have all been associated with the emergence of viral resistance… read more here.
Keywords: combination; oseltamivir; influenza; resistance ... See more keywords
Efficient drug development of oseltamivir capsules based on process control, bioequivalence and PBPK modeling
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DOI: 10.1080/03639045.2022.2102647
Abstract: Abstract Oseltamivir phosphate is used to treat influenza. For registration of a generic product, bioequivalence studies are crucial, however, in vitro studies can sometimes replace the conventional human pharmacokinetic. To assess whether the dissolution profile… read more here.
Keywords: oseltamivir; bioequivalence; pbpk; drug development ... See more keywords
Binding mechanism of oseltamivir and influenza neuraminidase suggests perspectives for the design of new anti-influenza drugs
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DOI: 10.1371/journal.pcbi.1010343
Abstract: Oseltamivir is a widely used influenza virus neuraminidase (NA) inhibitor that prevents the release of new virus particles from host cells. However, oseltamivir-resistant strains have emerged, but effective drugs against them have not yet been… read more here.
Keywords: oseltamivir; design new; mechanism oseltamivir; binding mechanism ... See more keywords
Inhibition of Influenza Virus Replication by Oseltamivir Derivatives
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DOI: 10.3390/pathogens11020237
Abstract: Characterized by the high morbidity and mortality and seasonal surge, the influenza virus (IV) remains a major public health challenge. Oseltamivir is commonly used as a first-line antiviral. As a neuraminidase inhibitor, it attenuates the… read more here.
Keywords: influenza virus; oseltamivir resistant; oseltamivir; inhibition influenza ... See more keywords