Design, in silico studies, synthesis and in vitro evaluation of oseltamivir derivatives as inhibitors of neuraminidase from influenza A virus H1N1.
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DOI: 10.1016/j.ejmech.2017.01.039
Abstract: Since the neuraminidase (NA) enzyme of the influenza A virus plays a key role in the process of release of new viral particles from a host cell, it is often a target for new drug… read more here.
Keywords: h1n1; oseltamivir derivatives; design silico; influenza virus ... See more keywords
Discovery of C-1 modified oseltamivir derivatives as potent influenza neuraminidase inhibitors.
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DOI: 10.1016/j.ejmech.2018.01.050
Abstract: Inspired by our initial discovery about a series of neuraminidase (NA) inhibitors targeting the 150-cavity, in present study, we designed, synthesized, and biologically tested a panel of novel oseltamivir derivatives with C-1 modification, targeting the… read more here.
Keywords: oseltamivir derivatives; modified oseltamivir; group; discovery modified ... See more keywords
Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies.
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DOI: 10.1016/j.ejmech.2019.111635
Abstract: The discovery of novel potent neuraminidase (NA) inhibitors remains an attractive approach for treating infectious diseases caused by influenza. In this study, we describe the design and synthesis of novel N-substituted oseltamivir derivatives for probing… read more here.
Keywords: design synthesis; oseltamivir derivatives; substituted oseltamivir; novel substituted ... See more keywords
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00929
Abstract: On the basis of our earlier discovery of N1-selective inhibitors, the 150-cavity of influenza virus neuraminidases (NAs) could be further exploited to yield more potent oseltamivir derivatives. Among the synthesized compounds, 15b and 15c were… read more here.
Keywords: substituted oseltamivir; oseltamivir derivatives; derivatives potent; group ... See more keywords