Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906
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DOI: 10.1038/s41598-017-04304-5
Abstract: Growth factor signaling via insulin receptor (IR) and IGF-1 receptor (IGF1R) plays several important roles in the pathogenesis of metabolic syndrome and diabetes. OSI-906 (linsitinib), an anti-tumor drug, is an orally bioavailable dual inhibitor of… read more here.
Keywords: liver steatosis; recovery; osi 906; cell proliferation ... See more keywords