Response to osimertinib plus trametinib in a heavily treated epidermal growth factor receptor (EGFR)-positive NSCLC harboring a rare, acquired rapidly accelerated fibrosarcoma B-type (BRAF) p.D594N mutation: a case report.
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DOI: 10.1097/cad.0000000000001367
Abstract: Heterogeneity in the acquired genetic cause of osimertinib resistance leads to difficulties in understanding and addressing molecular mechanisms of resistance in clinical practice. Recent studies and clinical cases established that altered BRAF could drive osimertinib… read more here.
Keywords: d594n mutation; braf d594n; osimertinib plus; resistance ... See more keywords
Clinical outcomes and safety of osimertinib plus anlotinib for patients with previously treated EGFR T790M-positive NSCLC: A retrospective study.
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DOI: 10.1111/jcpt.13591
Abstract: WHAT IS KNOWN AND OBJECTIVE Although osimertinib achieved convincing efficacy for patients with EGFR T790M-positive non-small-cell lung cancer (NSCLC) as second-line treatment in the AURA3 clinical trials, patients developed drug resistance ultimately. Therefore, the present… read more here.
Keywords: t790m positive; plus anlotinib; study; safety ... See more keywords
Osimertinib plus Ramucirumab: The Best of Both Worlds?
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DOI: 10.1158/1078-0432.ccr-20-4026
Abstract: Both osimertinib and the combination of erlotinib plus ramucirumab are approved for initial therapy of advanced EGFR mutation–positive non–small cell lung cancer. Osimertinib is also approved in previously treated T790M mutation–positive patients. The accompanying article… read more here.
Keywords: plus ramucirumab; osimertinib plus; ramucirumab best; best worlds ... See more keywords