In situ analysis of osmolyte mechanisms of proteome thermal stabilization
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DOI: 10.1038/s41589-024-01568-7
Abstract: Organisms use organic molecules called osmolytes to adapt to environmental conditions. In vitro studies indicate that osmolytes thermally stabilize proteins, but mechanisms are controversial, and systematic studies within the cellular milieu are lacking. We analyzed… read more here.
Keywords: protein thermal; osmolyte; stabilization; analysis ... See more keywords
Hydration structure of osmolyte TMAO: concentration/pressure-induced response
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DOI: 10.1039/c6nj03296f
Abstract: Despite the well-known fact that the natural osmolyte trimethylamine-N-oxide (TMAO) is able to prevent protein denaturation and to stabilize the folded state of proteins in living cells under abiotic stress, much of its molecular mechanism… read more here.
Keywords: hydration structure; concentration pressure; hydration; osmolyte ... See more keywords