Regional oligodendrocytopathy and astrocytopathy precede myelin loss and blood–brain barrier disruption in a murine model of osmotic demyelination syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23268
Abstract: The osmotic demyelination syndrome (ODS) is a non‐primary inflammatory disorder of the central nervous system myelin that is often associated with a precipitous rise of serum sodium concentration. To investigate the physiopathology of ODS in… read more here.
Keywords: murine model; demyelination; brain; osmotic demyelination ... See more keywords
Can osmotic demyelination syndrome be a complication of liver failure?
Sign Up to like & getrecommendations! Published in 2020 at "eNeurologicalSci"
DOI: 10.1016/j.ensci.2020.100223
Abstract: This case demonstrates that osmotic demyelination syndrome (ODS) can occur in absence of hyponatremia in patients with fulminant liver failure and markedly high bilirubin levels. Extremely high bilirubin levels, such as >900 μmol/L in the… read more here.
Keywords: demyelination syndrome; failure; liver failure; osmotic demyelination ... See more keywords
Osmotic Demyelination Syndrome in Children.
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric neurology"
DOI: 10.1016/j.pediatrneurol.2019.03.018
Abstract: Osmotic demyelination syndrome is an acute demyelination process that usually occurs several days following an osmotic stress. This syndrome is rare in adults (0.4% to 0.56%) and even more uncommon in children. We performed a… read more here.
Keywords: myelinolysis; syndrome children; demyelination syndrome; demyelination ... See more keywords
Hyperammonemia in the setting of Roux-en-Y gastric bypass presenting with osmotic demyelination syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Community Hospital Internal Medicine Perspectives"
DOI: 10.1080/20009666.2021.1952522
Abstract: ABSTRACT Hyperammonemia can lead to serious outcomes including brain herniation, coma and death. It is often attributed to liver disease, specifically in association with alcohol use. However, in the absence of liver pathology, it can… read more here.
Keywords: demyelination; gastric bypass; hyperammonemia; demyelination syndrome ... See more keywords
Therapeutic challenges in the management of osmotic demyelination syndrome
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DOI: 10.1097/md.0000000000020283
Abstract: Abstract Rationale: There is an increasing and compelling need for early recognition of features of osmotic demyelination syndrome (ODS), and a further attempt at correcting this even where presentation is late. Patient concerns: A 49-year-old… read more here.
Keywords: demyelination syndrome; sodium; therapeutic challenges; challenges management ... See more keywords
Congenital nephrogenic diabetes insipidus presenting as osmotic demyelination syndrome in infancy
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000028552
Abstract: Abstract Rationale: Almost 90% of congenital nephrogenic diabetes insipidus (NDI) cases are caused by mutations in the arginine vasopressin receptor 2 gene, which has X-linked recessive inheritance. Although NDI is commonly diagnosed in early infancy… read more here.
Keywords: osmotic demyelination; congenital nephrogenic; nephrogenic diabetes; diagnosis ... See more keywords
Sequential Brain Perfusion Findings in a Case of Osmotic Demyelination Syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000004450
Abstract: ABSTRACT A 60-year-old man with chronic alcoholism for 30 years was admitted to the hospital for an acute alcoholic syndrome with global confusional state, cognitive disorders, and ataxia. MRI detected bilateral mamillary bodies T2 hypersignal… read more here.
Keywords: osmotic demyelination; brain perfusion; perfusion; demyelination syndrome ... See more keywords
Fatal osmotic demyelination following urgent start hemodialysis in a patient with normal serum sodium
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DOI: 10.1111/hdi.13184
Abstract: End stage kidney disease (ESKD) patients in the developing countries often present late for dialysis initiation with advanced uremia and life‐threatening complications. Urgent start dialysis in such emergent situations exposes the patient to risk of… read more here.
Keywords: urgent start; demyelination syndrome; following urgent; osmotic demyelination ... See more keywords
Osmotic demyelination syndrome in type 1 diabetes in the absence of dyselectrolytaemia: an overlooked complication?
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DOI: 10.1136/bcr-2016-219148
Abstract: Central pontine myelinolysis (CPM) is a demyelinating disorder of central nervous system which involves central portion of the pons and sometimes extrapontine areas also. It is commonly reported in settings of hyponatraemia or its rapid… read more here.
Keywords: diabetes absence; syndrome type; demyelination syndrome; type diabetes ... See more keywords
Severe osmotic demyelination syndrome with cortical involvement in the context of severe hyponatremia and central diabetes insipidus: an uncommon presentation of an unusual combination
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DOI: 10.1136/bcr-2023-257210
Abstract: Background: Osmotic demyelination syndrome (ODS) with cerebral cortical involvement is a rare complication of severe hyponatremia correction. Careful management of hyponatremia is crucial, particularly in patients with risk factors, such as alcohol use disorder and… read more here.
Keywords: demyelination syndrome; osmotic demyelination; diabetes insipidus; cortical involvement ... See more keywords
Osmotic demyelination syndrome: revisiting the diagnostic criteria through two fatal cases
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DOI: 10.1186/s12883-024-03934-3
Abstract: Osmotic Demyelination Syndrome (ODS) encompasses Central Pontine Myelinolysis and Extrapontine Myelinolysis, both of which are serious neurological conditions linked to the overly rapid correction of hyponatremia. Despite growing evidence, the exact etiology of ODS remains… read more here.
Keywords: demyelination syndrome; osmotic demyelination; hyponatremia; correction ... See more keywords