Therapeutic potential of phosphodiesterase inhibitors in the treatment of osteoporosis: scopes for therapeutic repurposing and discovery of new oral osteoanabolic drugs.
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DOI: 10.1016/j.ejphar.2021.174015
Abstract: Cyclic nucleotide phosphodiesterases (PDEs) are ubiquitously expressed enzymes that hydrolyse phosphodiester bond in the second messenger molecules including cAMP and cGMP. A wide range of drugs blocks one or more PDEs thereby preventing the inactivation… read more here.
Keywords: pde inhibitors; treatment; camp cgmp; osteoanabolic drugs ... See more keywords