Heparanase is expressed in adult human osteoarthritic cartilage and drives catabolic responses in primary chondrocytes.
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DOI: 10.1016/j.joca.2018.05.013
Abstract: OBJECTIVES The chondrocytes' pericellular matrix acts as a mechanosensor by sequestering growth factors that are bound to heparan sulfate (HS) proteoglycans. Heparanase is the sole mammalian enzyme with HS degrading endoglycosidase activity. Here, we aimed… read more here.
Keywords: heparanase; primary chondrocytes; adult human; osteoarthritic cartilage ... See more keywords
The Role of Autophagy in Osteoarthritic Cartilage
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DOI: 10.3390/biom12101357
Abstract: Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy… read more here.
Keywords: role autophagy; osteoarthritic cartilage; cartilage; autophagy osteoarthritic ... See more keywords
Advances in Research on the Regulatory Roles of lncRNAs in Osteoarthritic Cartilage
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DOI: 10.3390/biom13040580
Abstract: Osteoarthritis (OA) is the most common degenerative bone and joint disease that can lead to disability and severely affect the quality of life of patients. However, its etiology and pathogenesis remain unclear. It is currently… read more here.
Keywords: regulatory roles; cartilage; lncrnas osteoarthritic; osteoarthritic cartilage ... See more keywords