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   Articles with "osteoarthritic cartilage" as a keyword



Heparanase is expressed in adult human osteoarthritic cartilage and drives catabolic responses in primary chondrocytes.

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recommendations! Published in 2018 at "Osteoarthritis and cartilage"

DOI: 10.1016/j.joca.2018.05.013

Abstract: OBJECTIVES The chondrocytes' pericellular matrix acts as a mechanosensor by sequestering growth factors that are bound to heparan sulfate (HS) proteoglycans. Heparanase is the sole mammalian enzyme with HS degrading endoglycosidase activity. Here, we aimed… read more here.

Keywords: heparanase; primary chondrocytes; adult human; osteoarthritic cartilage ... See more keywords

The Role of Autophagy in Osteoarthritic Cartilage

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recommendations! Published in 2022 at "Biomolecules"

DOI: 10.3390/biom12101357

Abstract: Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy… read more here.

Keywords: role autophagy; osteoarthritic cartilage; cartilage; autophagy osteoarthritic ... See more keywords

Advances in Research on the Regulatory Roles of lncRNAs in Osteoarthritic Cartilage

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recommendations! Published in 2023 at "Biomolecules"

DOI: 10.3390/biom13040580

Abstract: Osteoarthritis (OA) is the most common degenerative bone and joint disease that can lead to disability and severely affect the quality of life of patients. However, its etiology and pathogenesis remain unclear. It is currently… read more here.

Keywords: regulatory roles; cartilage; lncrnas osteoarthritic; osteoarthritic cartilage ... See more keywords

Metabolomic Profiles and Pathways in Osteoarthritic Human Cartilage: A Comparative Analysis with Healthy Cartilage

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recommendations! Published in 2024 at "Metabolites"

DOI: 10.3390/metabo14040183

Abstract: Osteoarthritis (OA) is a chronic joint disease with heterogenous metabolic pathology. To gain insight into OA-related metabolism, metabolite extracts from healthy (n = 11) and end-stage osteoarthritic cartilage (n = 35) were analyzed using liquid… read more here.

Keywords: metabolomic profiles; healthy cartilage; human cartilage; cartilage ... See more keywords

BCLAF1 Regulates Osteoarthritic Cartilage Degradation Through Interaction with LAMTOR2

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recommendations! Published in 2025 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.100396

Abstract: Osteoarthritis (OA) is a progressive degenerative joint disorder with cartilage degradation as the primary cause of joint pain and loss of joint function. B-cell lymphoma-2-associated transcription factor 1 (BCLAF1) is a key regulator of apoptosis… read more here.

Keywords: osteoarthritic cartilage; cartilage; bclaf1 regulates; cartilage degradation ... See more keywords