Comparison of Face-to-Face vs Digital Delivery of an Osteoarthritis Treatment Program for Hip or Knee Osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.40126
Abstract: Key Points Question Is there a clinically relevant difference in joint pain reduction between a 3-month face-to-face or digitally delivered first-line intervention for persons with knee or hip osteoarthritis? Findings In this cohort study of… read more here.
Keywords: face; hip; osteoarthritis; face face ... See more keywords
Bioengineered Versatile Heterojunctions as Stress Busters Targeting Matrix Degradation and Ferroptosis for Osteoarthritis Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202419400
Abstract: Osteoarthritis (OA) is a chronic joint disease characterized by degeneration of articular cartilage, with the underlying mechanism being the inability of chondrocytes to maintain homeostasis in response to the changing stress. The stress response triggered… read more here.
Keywords: mbm; stress; bio heterojunction; ferroptosis ... See more keywords
Charge‐Guided Cartilage‐Penetrating Micro/Nanocarriers That Inhibit Piezo1 and Protect Cartilage to Alleviate Osteoarthritis
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DOI: 10.1002/adfm.202422280
Abstract: Osteoarthritis (OA), characterized by progressive cartilage degeneration and chronic joint pain, represents a major global health challenge. While intra‐articular drug delivery is a common therapeutic approach, its efficacy is limited by poor drug penetration through… read more here.
Keywords: micro nanocarriers; cartilage; penetration; charge guided ... See more keywords
Ultrasound‐Propelled Antioxidant Nanobowls for the Treatment of Osteoarthritis
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DOI: 10.1002/adfm.202523507
Abstract: Osteoarthritis is a major global health concern, characterized by progressive degradation of articular cartilage and excessive accumulation of reactive oxygen species (ROS). Although intra‐articular drug delivery is a commonly employed therapeutic approach, its effectiveness is… read more here.
Keywords: treatment; antioxidant nanobowls; ultrasound propelled; propelled antioxidant ... See more keywords
Therapeutic Controlled Release Strategies for Human Osteoarthritis
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202402737
Abstract: Osteoarthritis is a progressive, irreversible debilitating whole joint disease that affects millions of people worldwide. Despite the availability of various options (non‐pharmacological and pharmacological treatments and therapy, orthobiologics, and surgical interventions), none of them can… read more here.
Keywords: therapeutic controlled; release; release strategies; controlled release ... See more keywords
Trimanganese Tetroxide Nanozyme protects Cartilage against Degeneration by Reducing Oxidative Stress in Osteoarthritis.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202205859
Abstract: Osteoarthritis, a chronic degenerative cartilage disease, is the leading cause of movement disorders among humans. Although the specific pathogenesis and associated mechanisms remain unclear, oxidative stress-induced metabolic imbalance in chondrocytes plays a crucial role in… read more here.
Keywords: hydrogel; oxidative stress; osteoarthritis; mn3 ... See more keywords
Circular RNA Gtdc1 Protects Against Offspring Osteoarthritis Induced by Prenatal Prednisone Exposure by Regulating SRSF1‐Fn1 Signaling
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202307442
Abstract: Chondrodysplasia is closely associated with low birth weight and increased susceptibility to osteoarthritis in adulthood. Prenatal prednisone exposure (PPE) can cause low birth weight; however, its effect on offspring cartilage development remains unexplored. Herein, rats… read more here.
Keywords: srsf1 fn1; chondrodysplasia; prednisone exposure; prenatal prednisone ... See more keywords
Ultra‐Long‐Term Anti‐Inflammatory Polyphenol Capsule to Remodel the Microenvironment for Accelerating Osteoarthritis Healing by Single Dosage
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DOI: 10.1002/advs.202407425
Abstract: Osteoarthritis (OA) is a common chronic inflammatory disease that leads to disability and death. Existing therapeutic agents often require frequent use, which can lead to drug resistance and long‐term side effects. Polyphenols have anti‐inflammatory and… read more here.
Keywords: long term; polyphenol capsule; capsule; anti inflammatory ... See more keywords
Nanodrugs Targeting Key Factors of Ferroptosis Regulation for Enhanced Treatment of Osteoarthritis
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DOI: 10.1002/advs.202412817
Abstract: Osteoarthritis (OA) is a globally prevalent degenerative joint disease. Recent studies highlight the role of ferroptosis in OA progression. Targeting ferroptosis regulation presents a promising therapeutic strategy for OA; however, current research primarily focuses on… read more here.
Keywords: treatment; nanodrugs targeting; ferroptosis regulation; ferroptosis ... See more keywords
Rejuvenating Hyaline Cartilage with Senescence‐Targeting Si‐ADAM19 Delivery for Osteoarthritis Therapy
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DOI: 10.1002/advs.202414419
Abstract: Osteoarthritis (OA) is one of the most common joint degenerative diseases without effective treatment, whose pathology is related to the local accumulation of senescent cells (SnCs). However, existing SnCs‐scavenging drugs “senolytics” may lead to the… read more here.
Keywords: senescence; delivery; cartilage; hyaline cartilage ... See more keywords
Molten‐Salt‐Mediated Synthesis of Atomic Manganese/Cobalt Catalysts on Bioceramic Microparticles for Catalytic Anti‐Osteoarthritis Treatments
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DOI: 10.1002/advs.202505500
Abstract: Osteoarthritis (OA) is a chronic progressive joint disease characterized by cartilage degeneration and local inflammation, and its progression is closely related to the excessive production of reactive oxygen species (ROS). Despite progress made with small… read more here.
Keywords: molten salt; catalytic anti; salt mediated; akt mps ... See more keywords