Comparison of Face-to-Face vs Digital Delivery of an Osteoarthritis Treatment Program for Hip or Knee Osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.40126
Abstract: Key Points Question Is there a clinically relevant difference in joint pain reduction between a 3-month face-to-face or digitally delivered first-line intervention for persons with knee or hip osteoarthritis? Findings In this cohort study of… read more here.
Keywords: face; hip; osteoarthritis; face face ... See more keywords
Trimanganese Tetroxide Nanozyme protects Cartilage against Degeneration by Reducing Oxidative Stress in Osteoarthritis.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202205859
Abstract: Osteoarthritis, a chronic degenerative cartilage disease, is the leading cause of movement disorders among humans. Although the specific pathogenesis and associated mechanisms remain unclear, oxidative stress-induced metabolic imbalance in chondrocytes plays a crucial role in… read more here.
Keywords: hydrogel; oxidative stress; osteoarthritis; mn3 ... See more keywords
Suppression of ABCD2 dysregulates lipid metabolism via dysregulation of miR‐141:ACSL4 in human osteoarthritis
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3356
Abstract: Even though increasing evidence indicates the importance of peroxisomal lipid metabolism in regulating biological and pathological events, its involvement in cartilage development has not been well studied. Here, we identified the importance of peroxisomal function,… read more here.
Keywords: suppression; metabolism; acsl4 human; osteoarthritis ... See more keywords
Bisphosphonate Use Is Protective of Radiographic Knee Osteoarthritis Progression Among those With Low Disease Severity and Being Non‐Overweight: Data From the Osteoarthritis Initiative
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4133
Abstract: Antiresorptive medications have been explored for treating knee osteoarthritis (OA); however, little data exist on the effects of today's more potent nitrogen‐containing oral bisphosphonates on radiographic disease‐progression in patients with varying disease‐severity, especially those who… read more here.
Keywords: osteoarthritis; bisphosphonate use; bisphosphonate; knee ... See more keywords
Mice Lacking Wnt9a or Wnt4 Are Prone to Develop Spontaneous Osteoarthritis With Age and Display Alteration in Either the Trabecular or Cortical Bone Compartment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4569
Abstract: Osteoarthritis (OA) is a common degenerative disease of the joint, with a complex multifactorial not yet fully understood etiology. Over the past years, the Wnt signaling pathway has been implicated in osteoarthritis. In a recent… read more here.
Keywords: bone; age; osteoarthritis; wnt4 ... See more keywords
Adiponectin receptor agonist AdipoRon attenuates calcification of osteoarthritis chondrocytes by promoting autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29605
Abstract: Cartilage calcification contributes to the development and progression of osteoarthritis (OA). It has been well‐investigated adiponectin regulates vascular calcification. The purpose of this study is to investigate the therapeutic value and the molecular mechanism of… read more here.
Keywords: receptor agonist; osteoarthritis; calcification; adiporon ... See more keywords
Thermosensitive hybrid hyaluronan/p(HPMAm‐lac)‐PEG hydrogels enhance cartilage regeneration in a mouse model of osteoarthritis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28598
Abstract: Osteoarthritis (OA), due to cartilage degeneration, is one of the leading causes of disability worldwide. Currently, there are not efficacious therapies to reverse cartilage degeneration. In this study we evaluated the potential of hybrid hydrogels,… read more here.
Keywords: mouse model; osteoarthritis; cartilage; release ... See more keywords
Harpagoside suppresses IL‐6 expression in primary human osteoarthritis chondrocytes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.23262
Abstract: There is growing evidence in support of the involvement of inflammatory response in the pathogenesis of osteoarthritis (OA). Harpagoside, one of the bioactive components of Harpagophytum procumbens (Hp), has been shown to possess anti‐inflammatory properties.… read more here.
Keywords: suppresses expression; harpagoside suppresses; osteoarthritis; chondrocytes harpagoside ... See more keywords
Asymptomatic and symptomatic individuals with the same radiographic evidence of knee osteoarthritis walk with different knee moments and muscle activity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.23465
Abstract: There is an established discordance between the structural joint damage and clinical symptoms of knee osteoarthritis; however, there has been little investigation into the differences in joint level biomechanics and muscle activation patterns during gait… read more here.
Keywords: individuals radiographic; asymptomatic symptomatic; biomechanics; osteoarthritis ... See more keywords
Amniotic Suspension Allograft Modulates Inflammation in a Rat Pain Model of Osteoarthritis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.24559
Abstract: Osteoarthritis (OA) affects over 301 million adults worldwide. Inflammation is a recognized component of the OA process; two potent pro‐inflammatory cytokines involved in OA are interleukin‐1β and tumor necrosis factor‐α. Placental‐derived tissues and fluids are… read more here.
Keywords: amniotic suspension; suspension allograft; osteoarthritis; model ... See more keywords
Total lignans from Vitex negundo seeds attenuate osteoarthritis and their main component vitedoin A alleviates osteoclast differentiation by suppressing ERK/NFATc1 signaling
Sign Up to like & getrecommendations! Published in 2023 at "Phytotherapy Research"
DOI: 10.1002/ptr.7750
Abstract: The seeds of Vitex negundo have been used for inflammation‐related disease treatment in traditional medicine. This study focused on the anti‐osteoarthritis (OA) effects of the total lignans of V. negundo seeds (TOV) in monosodium iodoacetate‐induced… read more here.
Keywords: osteoclast differentiation; total lignans; osteoarthritis; negundo seeds ... See more keywords