Phospholipase A2 inhibitor–loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression
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DOI: 10.1126/sciadv.abe6374
Abstract: The engineered nanoparticles mitigate osteoarthritis progression. Treating osteoarthritis (OA) remains a major clinical challenge. Despite recent advances in drug discovery and development, no disease-modifying drug for knee OA has emerged with any notable clinical success,… read more here.
Keywords: inhibitor; mitigate osteoarthritis; osteoarthritis progression; loaded micellar ... See more keywords
Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression
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DOI: 10.1126/sciadv.abo7868
Abstract: Abnormal subchondral bone remodeling featured by over-activated osteoclastogenesis leads to articular cartilage degeneration and osteoarthritis (OA) progression, but the mechanism is still unclear. In this study, we used lymphocyte cytosolic protein 1 (Lcp1) knock-out mice… read more here.
Keywords: environment; bone; osteoarthritis progression; cartilage degeneration ... See more keywords
Four-Octyl Itaconate Protects Chondrocytes against H2O2-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling
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DOI: 10.1155/2022/2206167
Abstract: Nrf2 is a critical regulator of the antioxidant defense systems in cellular protection. Emerging evidence has shown that four-octyl itaconate (OI) activates Nrf2 cascade. In this study, the chondroprotective effects of OI on H2O2-stimulated chondrocytes… read more here.
Keywords: octyl itaconate; itaconate protects; progression; osteoarthritis progression ... See more keywords