Osteoblast-derived FGF9 regulates skeletal homeostasis.
Sign Up to like & getrecommendations! Published in 2017 at "Bone"
DOI: 10.1016/j.bone.2016.12.005
Abstract: FGF9 has complex and important roles in skeletal development and repair. We have previously observed that Fgf9 expression in osteoblasts (OBs) is regulated by G protein signaling and therefore the present study was done to… read more here.
Keywords: skeletal homeostasis; fgf9; osteoblast derived; fgf9ob ... See more keywords
Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28673-2
Abstract: Bone metabolism is regulated by the cooperative activity between bone-forming osteoblasts and bone-resorbing osteoclasts. However, the mechanisms mediating the switch between the osteoblastic and osteoclastic phases have not been fully elucidated. Here, we identify a… read more here.
Keywords: bone; bone formation; osteoblast derived; switch bone ... See more keywords
Preferential Lineage-Specific Differentiation of Osteoblast-Derived Induced Pluripotent Stem Cells into Osteoprogenitors
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells International"
DOI: 10.1155/2017/1513281
Abstract: While induced pluripotent stem cells (iPSCs) hold great clinical promise, one hurdle that remains is the existence of a parental germ-layer memory in reprogrammed cells leading to preferential differentiation fates. While it is problematic for… read more here.
Keywords: induced pluripotent; differentiation; pluripotent stem; osteoblast derived ... See more keywords
Corrigendum: Osteoblast-Derived Vesicle Protein Content Is Temporally Regulated During Osteogenesis: Implications for Regenerative Therapies
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2019.00392
Abstract: [This corrects the article DOI: 10.3389/fbioe.2019.00092.]. read more here.
Keywords: protein content; corrigendum osteoblast; vesicle protein; derived vesicle ... See more keywords
An ECM-Mimetic Hydrogel to Promote the Therapeutic Efficacy of Osteoblast-Derived Extracellular Vesicles for Bone Regeneration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.829969
Abstract: The use of extracellular vesicles (EVs) is emerging as a promising acellular approach for bone regeneration, overcoming translational hurdles associated with cell-based therapies. Despite their potential, EVs short half-life following systemic administration hinders their therapeutic… read more here.
Keywords: therapeutic efficacy; osteoblast derived; extracellular vesicles; collagen ... See more keywords
Osteoblast Derived Exosomes Alleviate Radiation- Induced Hematopoietic Injury
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.850303
Abstract: As hematopoietic stem cells can differentiate into all hematopoietic lineages, mitigating the damage to hematopoietic stem cells is important for recovery from overdose radiation injury. Cells in bone marrow microenvironment are essential for hematopoietic stem… read more here.
Keywords: derived exosomes; osteoblast derived; hematopoietic stem; radiation ... See more keywords
Imipramine Protects against Bone Loss by Inhibition of Osteoblast-Derived Microvesicles
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18051013
Abstract: The maintenance of bone homeostasis is largely dependent upon cellular communication between osteoclasts and osteoblasts. Microvesicles (MVs) represent a novel mechanism for osteoblasts and osteoclasts communication, as has been demonstrated in our previous study. Sphingomyelinases… read more here.
Keywords: loss inhibition; imipramine protects; bone loss; protects bone ... See more keywords