MiR‐17‐3p inhibits osteoblast differentiation by downregulating Sox6 expression
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12979
Abstract: Osteoporosis and osteoarthritis are orthopedic disorders that affect millions of elderly people worldwide; stimulation of bone formation is a potential therapeutic strategy for the treatment of these conditions. As the only bone‐forming cells, osteoblasts play… read more here.
Keywords: mir; differentiation; role; osteoblast differentiation ... See more keywords
A Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation
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DOI: 10.1002/adfm.201703569
Abstract: Little is known about the principles of surface structure design for orthopedic and dental implants. To find topographical groove patterns that could enhance osteoblast differentiation according to cell type, groove patterns are fabricated with ridges… read more here.
Keywords: osteoblast differentiation; groove pattern; differentiation; groove patterns ... See more keywords
Transient downregulation of NR4A1 leads to impaired osteoblast differentiation through the TGF-ß pathway, and Elesclomol (STA-4783) rescues this phenotype.
Sign Up to like & getrecommendations! Published in 2023 at "Cell biochemistry and function"
DOI: 10.1002/cbf.3814
Abstract: Bone formation is regulated by numerous factors, such as transcription factors, cytokines, and extracellular matrix molecules. Human hormone nuclear receptors (hHNR) are a family of ligand-regulated transcription factors that are activated by steroid hormones, such… read more here.
Keywords: tgf pathway; elesclomol sta; sta 4783; differentiation ... See more keywords
Zoledronate promotes osteoblast differentiation in high‐glucose conditions via the p38MAPK pathway
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DOI: 10.1002/cbin.11921
Abstract: Zoledronate (ZOL) were found to inhibit bone resorption in an animal model of diabetes, high glucose concentrations have been shown to decreased the osteogenesis‐related gene expression. But the molecular mechanism by which high glucose levels… read more here.
Keywords: expression; high glucose; differentiation; osteoblast differentiation ... See more keywords
Absorbable collagen sponges loaded with recombinant bone morphogenetic protein 9 induces greater osteoblast differentiation when compared to bone morphogenetic protein 2
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Dental Research"
DOI: 10.1002/cre2.55
Abstract: The use of growth factors for the regeneration of soft and hard tissues has been utilized extensively in dental medicine over the past decade. Recently our group found that recombinant human bone morphogenetic protein 9… read more here.
Keywords: osteoblast differentiation; rhbmp9; bone morphogenetic; morphogenetic protein ... See more keywords
Naphthenic acid fraction components from oil sands process‐affected water from the Athabasca Oil Sands Region impair murine osteoblast differentiation and function
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4370
Abstract: The extraction of bitumen from surface mining in the Athabasca Oil Sands Region (AOSR) produces large quantities of oil sands process‐affected water (OSPW) that needs to be stored in settling basins near extraction sites. Chemical… read more here.
Keywords: oil; oil sands; osteoblast differentiation; sands region ... See more keywords
Hop2 Interacts with ATF4 to Promote Osteoblast Differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3857
Abstract: Activating transcription factor 4 (ATF4) is a member of the basic leucine zipper (bZip) transcription factor family required for the terminal differentiation of osteoblasts. Despite its critical importance as one of the three main osteoblast… read more here.
Keywords: transcription; hop2; differentiation; mice ... See more keywords
Pseudoshikonin I enhances osteoblast differentiation by stimulating Runx2 and Osterix
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DOI: 10.1002/jcb.26238
Abstract: Pseudoshikonin I (PSI), a novel biomaterial isolated from Lithospermi radix, has been recognized as an herbal medicine for the treatment of infectious and inflammatory diseases. Bone remodeling maintains a balance through bone resorption (osteoclastogenesis) and… read more here.
Keywords: runx2 osterix; pseudoshikonin; enhances osteoblast; differentiation stimulating ... See more keywords
FOXC1 negatively regulates BMP‐SMAD activity and Id1 expression during osteoblast differentiation
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DOI: 10.1002/jcb.29595
Abstract: Bone morphogenetic proteins regulate a diverse range of biological processes through their activation of SMAD1, SMAD5, or SMAD8 proteins that, in turn, regulate gene expression. These SMAD transcription factors achieve a layer of functional specificity… read more here.
Keywords: foxc1; expression; differentiation; osteoblast differentiation ... See more keywords
MicroRNA‐224 suppresses osteoblast differentiation by inhibiting SMAD4
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26596
Abstract: Osteoblast differentiation was found to be regulated by a variety of cell signaling and intracellular regulatory factors. In this study, we aimed at investigating the regulatory effect of microRNA‐224 on osteoblast differentiation and its molecular… read more here.
Keywords: mir 224; microrna 224; differentiation; osteoblast differentiation ... See more keywords
RUNX2 co‐operates with EGR1 to regulate osteogenic differentiation through Htra1 enhancers
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29704
Abstract: Runt‐related transcription factor 2 (Runx2) has been shown to regulate osteoblast differentiation by directly or indirectly regulating numerous osteoblast‐related genes. However, our understanding of the transcriptional mechanisms of RUNX2 is mainly restricted to its transactivation,… read more here.
Keywords: htra1 enhancers; runx2; differentiation; osteoblast differentiation ... See more keywords