Targeting heme-oxidized soluble guanylate cyclase to promote osteoblast function.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.12.004
Abstract: The enzyme soluble guanylate cyclase (sGC) plays an essential part in the nitric oxide (NO) signaling pathway by binding to the prosthetic heme group; thereby catalyzing the synthesis of cyclic guanosine monophosphate (cGMP)-dependent protein kinases.… read more here.
Keywords: osteoblast function; heme oxidized; soluble guanylate; guanylate cyclase ... See more keywords
Zika virus infection perturbs osteoblast function
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35422-3
Abstract: Zika virus (ZIKV) infection is typically characterized by a mild self-limiting disease presenting with fever, rash, myalgia and arthralgia and severe fetal complications during pregnancy such as microcephaly, subcortical calcifications and arthrogyropsis. Virus-induced arthralgia due… read more here.
Keywords: osteoblast function; infection; zikv infection; zikv ... See more keywords
NIPA2 regulates osteoblast function by modulating mitophagy in type 2 diabetes osteoporosis
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DOI: 10.1038/s41598-020-59743-4
Abstract: The highly selective magnesium transporter non-imprinted in Prader-Willi/Angelman syndrome region protein 2 (NIPA2) has recently been associated with the development and progression of type 2 diabetes osteoporosis, but the mechanisms involved are still poorly understood.… read more here.
Keywords: diabetes osteoporosis; type diabetes; osteoblast function; nipa2 regulates ... See more keywords
Dual Effects of Lipid Metabolism on Osteoblast Function
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.578194
Abstract: The skeleton is a dynamic and metabolically active organ with the capacity to influence whole body metabolism. This newly recognized function has propagated interest in the connection between bone health and metabolic dysfunction. Osteoblasts, the… read more here.
Keywords: osteoblast function; metabolism; effects lipid; dual effects ... See more keywords
Enhancement of Osteoblast Function through Extracellular Vesicles Derived from Adipose-Derived Stem Cells
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DOI: 10.3390/biomedicines10071752
Abstract: Adipose-derived stem cells (ADSCs) are a type of mesenchymal stem cell that is investigated in bone tissue engineering (BTE). Osteoblasts are the main cells responsible for bone formation in vivo and directing ADSCs to form… read more here.
Keywords: stem; adsc evs; adipose derived; osteoblast function ... See more keywords
Influence of Cholesterol on the Regulation of Osteoblast Function
Sign Up to like & getrecommendations! Published in 2023 at "Metabolites"
DOI: 10.3390/metabo13040578
Abstract: Bone is a dynamic tissue composed of cells, an extracellular matrix, and mineralized portion. Osteoblasts are responsible for proper bone formation and remodeling, and function. These processes are endergonic and require cellular energy in the… read more here.
Keywords: function; bone; cholesterol regulation; influence cholesterol ... See more keywords