3D Printing Hydrogel Scaffolds with Nanohydroxyapatite Gradient to Effectively Repair Osteochondral Defects in Rats
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202006697
Abstract: Osteochondral (OC) defects pose an enormous challenge with no entirely satisfactory repair strategy to date. Herein, a 3D printed gradient hydrogel scaffold with a similar structure to that of OC tissue is designed, involving a… read more here.
Keywords: hydrogel scaffolds; scaffolds nanohydroxyapatite; printing hydrogel; defects rats ... See more keywords
WNT3A‐loaded exosomes enable cartilage repair
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12088
Abstract: Abstract Cartilage defects repair poorly. Recent genetic studies suggest that WNT3a may contribute to cartilage regeneration, however the dense, avascular cartilage extracellular matrix limits its penetration and signalling to chondrocytes. Extracellular vesicles actively penetrate intact… read more here.
Keywords: osteochondral defects; cartilage; loaded exosomes; wnt3a loaded ... See more keywords
Surgical Treatment Paradigms of Ankle Lateral Instability, Osteochondral Defects and Impingement.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-76735-2_4
Abstract: Ankle sprain is amongst the most frequent musculoskeletal injuries, particularly during sports activities. Chronic ankle instability (CAI) resulting from an ankle sprain might have severe long-lasting consequences on the ankle joint. Despite the fact that… read more here.
Keywords: surgical treatment; osteochondral defects; treatment; treatment paradigms ... See more keywords
Treatment of osteochondral defects: chondrointegration of metal implants improves after hydroxyapatite coating
Sign Up to like & getrecommendations! Published in 2019 at "Knee Surgery, Sports Traumatology, Arthroscopy"
DOI: 10.1007/s00167-019-05484-5
Abstract: PurposeThe treatment of osteochondral defects in joint cartilage remains challenging due to its limited repair capacity. This study presents a metallic osteochondral plug with hydroxyapatite (HA)-coated cap edges for improved implant-tissue contact. The hypothesis was… read more here.
Keywords: osteochondral defects; treatment osteochondral; tissue; cap ... See more keywords
Efficacy and safety of autologous chondrocyte implantation for osteochondral defects of the talus: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Orthopaedic and Trauma Surgery"
DOI: 10.1007/s00402-021-03990-1
Abstract: Studies have reported various effects of autologous chondrocyte implantation (ACI) on osteochondral defects of the talus. Therefore, to assess the effectiveness of ACI for osteochondral defects of the talus, we used the meta-analytic approach. Electronic… read more here.
Keywords: osteochondral defects; analysis; chondrocyte implantation; autologous chondrocyte ... See more keywords
Repair of Osteochondral Defects in Rabbit Knee Using Menstrual Blood Stem Cells Encapsulated in Fibrin Glue: A Good Stem Cell Candidate for the Treatment of Osteochondral Defects
Sign Up to like & getrecommendations! Published in 2019 at "Tissue Engineering and Regenerative Medicine"
DOI: 10.1007/s13770-019-00189-9
Abstract: AbstactBackground:In recent years, researchers discovered that menstrual blood-derived stem cells (MenSCs) have the potential to differentiate into a wide range of tissues including the chondrogenic lineage. In this study, we aimed to investigate the effect… read more here.
Keywords: osteochondral defects; menstrual blood; menscs; encapsulated fibrin ... See more keywords
Seamless and early gap healing of osteochondral defects by autologous mosaicplasty combined with bioactive supramolecular nanofiber-enabled gelatin methacryloyl (BSN-GelMA) hydrogel
Sign Up to like & getrecommendations! Published in 2022 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2022.03.038
Abstract: Autologous mosaicplasty is a common approach used to treat osteochondral defects in clinical practice. Gap integration between host and transplanted plugs requires bone tissue reservation and hyaline cartilage regeneration without uneven surface, graft necrosis and… read more here.
Keywords: gap; bsn gelma; gelma; osteochondral defects ... See more keywords
3D bio-printed biphasic scaffolds with dual modification of silk fibroin for the integrated repair of osteochondral defects.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials science"
DOI: 10.1039/d1bm00535a
Abstract: Repair of osteochondral defects is still a challenge, especially the regeneration of hyaline cartilage. Parathyroid hormone (PTH) can inhibit the hypertrophy of chondrocytes to maintain the phenotype of hyaline cartilage. Here, we aimed to construct… read more here.
Keywords: pth; osteochondral defects; hyaline cartilage; repair osteochondral ... See more keywords
Bionic biphasic composite scaffolds with osteochondrogenic factors for regeneration of full-thickness osteochondral defects.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00103a
Abstract: Full-thickness osteochondral defects lack the capability to self-repair owing to their complicated hierarchical structure. At present, clinical treatments including microfracture etc. have shown some efficacy; however, the newborn tissue exhibits some drawbacks, such as fibrocartilage… read more here.
Keywords: thickness osteochondral; full thickness; repair; osteochondrogenic factors ... See more keywords
The Expression Levels and Significance of GSH, MDA, SOD, and 8-OHdG in Osteochondral Defects of Rabbit Knee Joints
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/6916179
Abstract: Objective To observe the dynamic changes in oxidative stress and the expression levels of antioxidant and oxidative parameters in the blood and synovial fluid in the osteochondral defects of the rabbit knee joints and to… read more here.
Keywords: expression; group; rabbit knee; expression levels ... See more keywords
Healing of Osteochondral Defects via Endochondral Ossification in an Ovine Model
Sign Up to like & getrecommendations! Published in 2019 at "CARTILAGE"
DOI: 10.1177/1947603517713818
Abstract: Objective The objective of this study was to describe the mechanism of healing of osteochondral defects of the distal femur in the sheep, a commonly used translational model. Information on the healing mechanism be useful… read more here.
Keywords: via endochondral; healing osteochondral; osteochondral defects; endochondral ossification ... See more keywords