Bioceramic Scaffolds with Antioxidative Functions for ROS Scavenging and Osteochondral Regeneration
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105727
Abstract: Osteoarthritis (OA) is a degenerative disease that involves excess reactive oxygen species (ROS) and osteochondral defects. Although multiple approaches have been developed for osteochondral regeneration, how to balance the biochemical and physical microenvironment in OA… read more here.
Keywords: regeneration; scaffolds antioxidative; ros scavenging; scavenging osteochondral ... See more keywords
Combination of Polymeric Supports and Drug Delivery Systems for Osteochondral Regeneration.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-76735-2_13
Abstract: Musculoskeletal conditions have been defined by European National Health systems as one of the key themes which should be featured during the present decade as a consequence of the significant healthcare and social support costs.… read more here.
Keywords: systems osteochondral; combination; drug delivery; delivery systems ... See more keywords
Gradient nano-engineered in situ forming composite hydrogel for osteochondral regeneration.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.01.056
Abstract: Fabrication of anisotropic osteochondral-mimetic scaffold with mineralized subchondral zone and gradient interface remains challenging. We have developed an injectable semi-interpenetrating network hydrogel construct with chondroitin sulfate nanoparticles (ChS-NPs) and nanohydroxyapatite (nHA) (∼30-90 nm) in chondral and… read more here.
Keywords: hydrogel; gradient; interface; nano engineered ... See more keywords
An injectable continuous stratified structurally and functionally biomimetic construct for enhancing osteochondral regeneration.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.11.017
Abstract: Osteochondral regeneration with the formation of hyaline cartilage and subchondral bone as well as the integration between the newly formed tissues with the host tissue still remains a great challenge. In this study, a construct… read more here.
Keywords: construct; regeneration; subchondral bone; bmscs ... See more keywords
Tannic acid-mediated dual peptide-functionalized scaffolds to direct stem cell behavior and osteochondral regeneration
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2020.125232
Abstract: Abstract The development of cell-instructive scaffolds, which provide biochemical cues to direct endogenous bone marrow-derived mesenchymal stem cells (BMSCs) behavior, has the potential to revolutionize osteochondral tissue engineering. However, scaffold material itself is generally lacking… read more here.
Keywords: tannic acid; regeneration; peptide functionalized; stem ... See more keywords
Modulation of 3D Printed Calcium-Deficient Apatite Constructs with Varying Mn Concentrations for Osteochondral Regeneration via Endochondral Differentiation.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c05110
Abstract: Osteochondral regeneration remains a vital problem in clinical situations affecting both bone and cartilage tissues due to the low regeneration ability of cartilage tissue. Additionally, the simultaneous regeneration of bone and cartilage is difficult to… read more here.
Keywords: regeneration; cartilage; bone cartilage; osteochondral regeneration ... See more keywords
Implication of Mesenchymal Stem Cells and Their Derivates for Osteochondral Regeneration
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052490
Abstract: Healing of articular cartilage defects presents a challenging issue, due to its regenerative shortcomings. Lacking vascularity and innervation of cartilage and low proliferative potential of chondrocytes are the main reasons for the limited healing potential… read more here.
Keywords: cartilage; cells derivates; osteochondral regeneration; mesenchymal stem ... See more keywords
Mesenchymal-Stromal-Cell-Conditioned Media and Their Implication for Osteochondral Regeneration
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24109054
Abstract: Despite significant advances in biomedical research, osteochondral defects resulting from injury, an autoimmune condition, cancer, or other pathological conditions still represent a significant medical problem. Even though there are several conservative and surgical treatment approaches,… read more here.
Keywords: regeneration; conditioned media; mesenchymal stromal; osteochondral regeneration ... See more keywords
Progress in 3D Bioprinting Technology for Osteochondral Regeneration
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14081578
Abstract: Osteochondral injuries can lead to osteoarthritis (OA). OA is characterized by the progressive degradation of the cartilage tissue together with bone tissue turnover. Consequently, joint pain, inflammation, and stiffness are common, with joint immobility and… read more here.
Keywords: regeneration; progress bioprinting; bioprinting technology; osteochondral regeneration ... See more keywords