Puerarin specifically disrupts osteoclast activation via blocking integrin-β3 Pyk2/Src/Cbl signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Orthopaedic Translation"
DOI: 10.1016/j.jot.2022.01.003
Abstract: Objective Given the limitations of current anti-resorption agents for postmenopausal osteoporosis, there is a need for alternatives without impairing coupling crosstalk between bone resorption and bone formation ie. osteoclastogenesis. Puerarin, a unique C-glycoside isoflavonoid, was… read more here.
Keywords: bone; activation; osteoclast activation; bone resorption ... See more keywords
Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF‐κB pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13291
Abstract: The main target of current drugs for alleviating bone loss is osteoclasts. However, the long‐term application of such drugs will also cause side effects. Therefore, it is of great need to develop new and safer… read more here.
Keywords: urolithin suppressed; osteoclast activation; loss; bone loss ... See more keywords
Molecular Hydrogen Prevents Osteoclast Activation in a Glucocorticoid-Induced Osteoporosis Zebrafish Scale Model
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DOI: 10.3390/antiox12020345
Abstract: Antioxidants represent a powerful tool for many human diseases and, in particular, molecular hydrogen has unique characteristics that make it a very promising therapeutic agent against osteoporosis. Zebrafish scales offer an innovative model in which… read more here.
Keywords: osteoclast activation; hydrogen; osteoporosis zebrafish; activity ... See more keywords
Plum-Derived Exosome-like Nanovesicles Induce Differentiation of Osteoblasts and Reduction of Osteoclast Activation
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DOI: 10.3390/nu15092107
Abstract: Osteoblasts and osteoclasts play crucial roles in bone formation and bone resorption. We found that plum-derived exosome-like nanovesicles (PENVs) suppressed osteoclast activation and modulated osteoblast differentiation. PENVs increased the proliferation, differentiation, and mineralization of osteoblastic… read more here.
Keywords: derived exosome; osteoclast activation; exosome like; plum derived ... See more keywords