Potential mechanisms of osteoprotegerin-induced damage to osteoclast adhesion structures via P2X7R-mediated MAPK signaling
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2022.5115
Abstract: Osteoprotegerin (OPG) is a negative regulator of osteoclast formation by competing with receptor activator of the nuclear factor-κB (NF-κB) ligand (RANKL) for RANK. OPG is not only a soluble decoy receptor for RANKL, but is… read more here.
Keywords: adhesion; mapk signaling; osteoclast adhesion; mediated mapk ... See more keywords
Selective regulation of osteoclast adhesion and spreading by PLCγ/PKCα-PKCδ/RhoA-Rac1 signaling
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DOI: 10.5483/bmbrep.2018.51.5.198
Abstract: Bone resorption by multinucleated osteoclasts is a multistep process involving adhesion to the bone matrix, migration to resorption sites, and formation of sealing zones and ruffled borders. Macrophage colony-stimulating factor (M-CSF) and osteopontin (OPN) have… read more here.
Keywords: plc pkc; adhesion spreading; osteoclast adhesion; pkc rhoa ... See more keywords