Dynamin‐related protein 1 positively regulates osteoclast differentiation and bone loss
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13963
Abstract: Dynamin‐related protein 1 (DRP1) is a mitochondrial membrane GTPase and regulates mitochondrial fission. In this study, we found that the cytokine RANKL increased the expression of DRP1 and its receptor proteins, Fis1, Mid49, and Mid… read more here.
Keywords: osteoclast differentiation; differentiation; bone loss; related protein ... See more keywords
Rab34 plays a critical role as a bidirectional regulator of osteoclastogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3691
Abstract: Accumulating evidence suggests that Rab GTPases representing the largest branch of Ras superfamily have recently emerged as the core factors for the regulation of osteoclastogenesis through modulating vesicular transport amongst specific subcellular compartments. Among these,… read more here.
Keywords: osteoclast differentiation; role; osteoclastogenesis; regulator ... See more keywords
Formononetin attenuates osteoclast differentiation and calcium loss by mediating transcription factor AP-1 in type I diabetic mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23042
Abstract: Formononetin (FMN) has been reported as a prospective antiosteoporotic medication. However, the antiosteoporotic properties of FMN are still unclear in a mouse model with diabetes-induced osteoporosis. An osteoporotic or osteopenic mouse model with type I diabetes… read more here.
Keywords: mice; osteoclast differentiation; fmn; type ... See more keywords
A novel Bruton's tyrosine kinase inhibitor, acalabrutinib, suppresses osteoclast differentiation and Porphyromonas gingivalis lipopolysaccharide-induced alveolar bone resorption.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontology"
DOI: 10.1002/jper.18-0334
Abstract: BACKGROUND Periodontitis is not only one of the most prevalent inflammatory diseases among adults, but also commonly linked to numerous systemic conditions including cardiovascular diseases, stroke, and diabetes. Although osteoclasts are responsible for the alveolar… read more here.
Keywords: osteoclast differentiation; bone resorption; induced alveolar; alveolar bone ... See more keywords
Total lignans from Vitex negundo seeds attenuate osteoarthritis and their main component vitedoin A alleviates osteoclast differentiation by suppressing ERK/NFATc1 signaling
Sign Up to like & getrecommendations! Published in 2023 at "Phytotherapy Research"
DOI: 10.1002/ptr.7750
Abstract: The seeds of Vitex negundo have been used for inflammation‐related disease treatment in traditional medicine. This study focused on the anti‐osteoarthritis (OA) effects of the total lignans of V. negundo seeds (TOV) in monosodium iodoacetate‐induced… read more here.
Keywords: osteoclast differentiation; total lignans; osteoarthritis; negundo seeds ... See more keywords
Effect of cadmium on Rho GTPases signal transduction during osteoclast differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23510
Abstract: Osteoclasts are the key target cells for cadmium (Cd)‐induced bone metabolism diseases, while Rho GTPases play an important role in osteoclast differentiation and bone resorption. To identify new therapeutic targets of Cd‐induced bone diseases; we… read more here.
Keywords: osteoclast differentiation; cadmium; signal transduction; rho gtpases ... See more keywords
Constant hypoxia inhibits osteoclast differentiation and bone resorption by regulating phosphorylation of JNK and IκBα
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation Research"
DOI: 10.1007/s00011-018-1209-9
Abstract: BackgroundOsteoclasts are responsible for the bone loss in rheumatoid arthritis (RA). Hypoxia has been suggested to play key roles in pathological bone loss. However, the current understanding of the effects of hypoxia on osteoclastogenesis is… read more here.
Keywords: hypoxia; bone; osteoclast differentiation; bone resorption ... See more keywords
RANKL as the master regulator of osteoclast differentiation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-020-01191-1
Abstract: RANKL, the essential cue for osteoclast differentiation, is the membrane-bound factor expressed by osteoclastogenesis-supporting cells such as osteoblasts and osteocytes. In vivo evidence indicates that RANKL functions as the indispensable and irreplaceable in the program… read more here.
Keywords: regulator osteoclast; osteoclast differentiation; master regulator; differentiation ... See more keywords
IL-3 inhibits rat osteoclast differentiation induced by TNF-α and other pro-osteoclastogenic cytokines.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biosciences"
DOI: 10.1007/s12038-021-00181-3
Abstract: IL-3, a haematopoiesis regulatory factor, has previously been shown to inhibit both mouse and human osteoclast differentiation and bone resorption. Here, the role of rat IL-3 on rat osteoclast differentiation was evaluated to address whether… read more here.
Keywords: osteoclast differentiation; differentiation induced; induced tnf; differentiation ... See more keywords
Autophagy-dependent mitochondrial function regulates osteoclast differentiation and maturation.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.155
Abstract: Bone homeostasis is maintained by bone remodeling, which involves continuous bone resorption by osteoclasts and bone formation by osteoblasts. Dysregulation of bone turnover, caused by osteoclast overactivation, causes destructive bone diseases. However, the mechanisms underlying… read more here.
Keywords: osteoclast differentiation; differentiation maturation; mitochondrial function; bone ... See more keywords
Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.115216
Abstract: Neutrophils are one of the most abundant leukocytes in the sites of lesion of inflammatory diseases such as periodontitis and rheumatoid arthritis. These diseases are accompanied by bone loss, which worsens the quality of life… read more here.
Keywords: degradation; osteoclast differentiation; elastase; enhanced osteoclast ... See more keywords