Dynamin‐related protein 1 positively regulates osteoclast differentiation and bone loss
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13963
Abstract: Dynamin‐related protein 1 (DRP1) is a mitochondrial membrane GTPase and regulates mitochondrial fission. In this study, we found that the cytokine RANKL increased the expression of DRP1 and its receptor proteins, Fis1, Mid49, and Mid… read more here.
Keywords: osteoclast differentiation; differentiation; bone loss; related protein ... See more keywords
Rab34 plays a critical role as a bidirectional regulator of osteoclastogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3691
Abstract: Accumulating evidence suggests that Rab GTPases representing the largest branch of Ras superfamily have recently emerged as the core factors for the regulation of osteoclastogenesis through modulating vesicular transport amongst specific subcellular compartments. Among these,… read more here.
Keywords: osteoclast differentiation; role; osteoclastogenesis; regulator ... See more keywords
Unraveling the Mechanisms That Regulate Osteoclast Differentiation: A Review of Current Advances
Sign Up to like & getrecommendations! Published in 2025 at "genesis"
DOI: 10.1002/dvg.70012
Abstract: Osteoporosis is a metabolic bone disease primarily caused by a decreased bone formation and increased bone resorption. Osteoclasts are a special class of terminally differentiated cells that play an important role in normal bone remodeling… read more here.
Keywords: differentiation; mechanisms regulate; regulate osteoclast; osteoclast differentiation ... See more keywords
Formononetin attenuates osteoclast differentiation and calcium loss by mediating transcription factor AP-1 in type I diabetic mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23042
Abstract: Formononetin (FMN) has been reported as a prospective antiosteoporotic medication. However, the antiosteoporotic properties of FMN are still unclear in a mouse model with diabetes-induced osteoporosis. An osteoporotic or osteopenic mouse model with type I diabetes… read more here.
Keywords: mice; osteoclast differentiation; fmn; type ... See more keywords
Molecular Mechanisms of Curdlan‐Induced Suppression of NFATc1 Expression in Osteoclasts
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30682
Abstract: Osteoclasts derived from hematopoietic stem cells express immunoreceptors on their cell surface. Previously, we showed that the β‐glucan curdlan suppressed osteoclastogenesis via binding to dectin‐1, a pattern recognition receptor. Curdlan negatively regulates osteoclast differentiation and… read more here.
Keywords: curdlan; raw cells; osteoclast differentiation; expression ... See more keywords
The RNA‐binding protein Cpeb4 regulates splicing of the Id2 gene in osteoclast differentiation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31197
Abstract: Cytoplasmic polyadenylation element‐binding protein 4 (Cpeb4) is an RNA‐binding protein that regulates posttranscriptional regulation, such as regulation of messenger RNA stability and translation. In the previous study, we reported that Cpeb4 localizes to nuclear bodies… read more here.
Keywords: cpeb4; osteoclast differentiation; rna binding; binding protein ... See more keywords
Loss of UCHL1 Leads to Enhanced Mouse Osteoclast Formation
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.70032
Abstract: Enhanced osteoclastogenesis causes bone fragility, osteoporosis, and an increased risk of fractures. Recent studies have suggested a possible correlation between osteoporosis and the pathological features of Parkinson's disease (PD). To establish a molecular link between… read more here.
Keywords: loss; enhanced mouse; osteoclast differentiation; loss uchl1 ... See more keywords
A novel Bruton's tyrosine kinase inhibitor, acalabrutinib, suppresses osteoclast differentiation and Porphyromonas gingivalis lipopolysaccharide-induced alveolar bone resorption.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontology"
DOI: 10.1002/jper.18-0334
Abstract: BACKGROUND Periodontitis is not only one of the most prevalent inflammatory diseases among adults, but also commonly linked to numerous systemic conditions including cardiovascular diseases, stroke, and diabetes. Although osteoclasts are responsible for the alveolar… read more here.
Keywords: osteoclast differentiation; bone resorption; induced alveolar; alveolar bone ... See more keywords
Total lignans from Vitex negundo seeds attenuate osteoarthritis and their main component vitedoin A alleviates osteoclast differentiation by suppressing ERK/NFATc1 signaling
Sign Up to like & getrecommendations! Published in 2023 at "Phytotherapy Research"
DOI: 10.1002/ptr.7750
Abstract: The seeds of Vitex negundo have been used for inflammation‐related disease treatment in traditional medicine. This study focused on the anti‐osteoarthritis (OA) effects of the total lignans of V. negundo seeds (TOV) in monosodium iodoacetate‐induced… read more here.
Keywords: osteoclast differentiation; total lignans; osteoarthritis; negundo seeds ... See more keywords
Effect of cadmium on Rho GTPases signal transduction during osteoclast differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23510
Abstract: Osteoclasts are the key target cells for cadmium (Cd)‐induced bone metabolism diseases, while Rho GTPases play an important role in osteoclast differentiation and bone resorption. To identify new therapeutic targets of Cd‐induced bone diseases; we… read more here.
Keywords: osteoclast differentiation; cadmium; signal transduction; rho gtpases ... See more keywords
Constant hypoxia inhibits osteoclast differentiation and bone resorption by regulating phosphorylation of JNK and IκBα
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation Research"
DOI: 10.1007/s00011-018-1209-9
Abstract: BackgroundOsteoclasts are responsible for the bone loss in rheumatoid arthritis (RA). Hypoxia has been suggested to play key roles in pathological bone loss. However, the current understanding of the effects of hypoxia on osteoclastogenesis is… read more here.
Keywords: hypoxia; bone; osteoclast differentiation; bone resorption ... See more keywords