Bone Microenvironment‐Suppressed T Cells Increase Osteoclast Formation and Osteolytic Bone Metastases in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4615
Abstract: Immunotherapies use components of the immune system, such as T cells, to fight cancer cells, and are changing cancer treatment, causing durable responses in some patients. Bone metastases are a debilitating complication in advanced breast… read more here.
Keywords: cell; osteoclast formation; bone; bone metastases ... See more keywords
Morin attenuates osteoclast formation and function by suppressing the NF‐κB, MAPK and calcium signalling pathways
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7229
Abstract: Morin is a natural compound isolated from moraceae family members and has been reported to possess a range of pharmacological activities. However, the effects of morin on bone‐associated disorders and the potential mechanism remain unknown.… read more here.
Keywords: mapk calcium; function; osteoclast formation; morin ... See more keywords
METTL14 represses osteoclast formation to ameliorate osteoporosis via enhancing GPX4 mRNA stability.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23829
Abstract: Excessive bone resorption by osteoclasts results in the development of multiple bone disorders including osteoporosis. This study aimed to explore the biological function of methyltransferase-like14 (METTL14) in osteoclast formation, as well as its related mechanisms.… read more here.
Keywords: via enhancing; bone; osteoporosis; formation ... See more keywords
Osteoclast formation, inflammation, and matrix metalloproteinase-9 are downregulated in bone repair following root canal treatment in dogs teeth.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical oral investigations"
DOI: 10.1007/s00784-021-03784-0
Abstract: OBJECTIVES The aim of this study was to investigate the inflammatory infiltrate, osteoclast formation, and expression of MMP-9 during the healing phase following root canal treatment in teeth with apical periodontitis. MATERIALS AND METHODS Apical… read more here.
Keywords: treatment; following root; osteoclast formation; canal treatment ... See more keywords
The Inverted U-Curve Association of Fluoride and Osteoclast Formation in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Biological Trace Element Research"
DOI: 10.1007/s12011-018-1624-3
Abstract: The effect of fluoride on osteoclasts is still controversial. In the past, researchers thought that the effects of fluoride on osteoclast and osteoblast formation occurred in a dose-dependent pattern. However, our previous in vitro study… read more here.
Keywords: inverted curve; treatment; group; formation ... See more keywords
Serpinb1a suppresses osteoclast formation
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.101004
Abstract: Serpinb1a, a serine protease inhibitor family protein, has been implicated in immunoregulation and several metabolic disorders, such as diabetes and obesity; however, its roles in bone remain unknown. Therefore, we herein investigated the physiological functions… read more here.
Keywords: serpinb1a suppresses; mrna levels; osteoclast formation; serpinb1a ... See more keywords
Pulsed electromagnetic fields inhibit human osteoclast formation and gene expression via osteoblasts.
Sign Up to like & getrecommendations! Published in 2018 at "Bone"
DOI: 10.1016/j.bone.2017.09.020
Abstract: Pulsed electromagnetic fields (PEMFs) can be effective in promoting the healing of delayed union or nonunion fractures. We previously reported that PEMF (Spinal-Stim® by Orthofix, Inc., Lewisville, TX) stimulated proliferation, differentiation and mineralization of rat… read more here.
Keywords: electromagnetic fields; gene expression; formation; osteoclast formation ... See more keywords
Tubeimoside I suppresses diabetes-induced bone loss in rats, osteoclast formation, and RANKL-induced nuclear factor-κB pathway.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106202
Abstract: Type 2 diabetes mellitus is often companied with osteoporosis, a process which involves osteoclast activation. In this study, we found tubeimoside I, a natural compound isolated from the Chinese medicinal herb Bolbostemma paniculatum (Maxim) Franquet… read more here.
Keywords: induced bone; tubeimoside suppresses; osteoclast formation; suppresses diabetes ... See more keywords
The Effect of Lunasin on Receptor Activator of Nuclear Factor Kappa‐B Ligand−mediated Osteoclast Formation from RAW 264.7 Cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Endodontics"
DOI: 10.1016/j.joen.2018.02.023
Abstract: Introduction: To date, no study has investigated the antiresorptive property of lunasin. Hence, the present study aimed to assess the ability of lunasin to inhibit the osteoclast formation using RAW 264.7 cells. We hypothesized that… read more here.
Keywords: mgr mol; osteoclast formation; lunasin; raw 264 ... See more keywords
Inhibitory effect of vanillin on RANKL‐induced osteoclast formation and function through activating mitochondrial‐dependent apoptosis signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.07.048
Abstract: &NA; Bone matrix homeostasis associated diseases such as osteoporosis and erosive arthritis were caused by the imbalance of osteoclast‐mediated bone‐resorption and osteoblast‐mediated bone‐formation. Suppressing the fusion and differentiation of osteoclast from osteoclast precursors are an… read more here.
Keywords: vanillin; formation; rankl induced; bone ... See more keywords
Osteopontin regulates macrophage activation and osteoclast formation in hypertensive patients with vascular calcification
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40253
Abstract: Vascular calcification (VC) is a highly regulated ectopic mineral deposition process involving immune cell infiltration in the vasculatures, which has been recognized to be promoted by hypertension. The matricellular glycoprotein osteopontin (OPN) is strongly induced… read more here.
Keywords: activation osteoclast; macrophage activation; vascular calcification; formation hypertensive ... See more keywords