CAV-1 regulates osteocyte communication with osteoclast and osteoblast precursors
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-08570-6
Abstract: Mechanical forces regulate bone homeostasis through complex mechanisms involving diverse mechanoreceptors in osteocytes. PTH/PTHrP receptor type I (PTH1R) regulates the communication with osteoclast precursors by translocating to the primary cilia in osteocytes. Caveolin-1 (CAV-1), the… read more here.
Keywords: osteocyte communication; osteoblast precursors; communication osteoclast; primary cilia ... See more keywords
PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjz028
Abstract: Abstract PIP5k1β is crucial to the generation of phosphotidylinosotol (4, 5)P2. PIP5k1β participates in numerous cellular activities, such as B cell and platelet activation, cell phagocytosis and endocytosis, cell apoptosis, and cytoskeletal organization. In the… read more here.
Keywords: osteoclast osteoblast; bone homeostasis; pip5k1; differentiation ... See more keywords
Ferroptosis-mediated osteoclast-osteoblast crosstalk: signaling pathways governing bone remodeling in osteoporosis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-025-06315-9
Abstract: Osteoporosis is a metabolic bone disease characterized by disruption of bone homeostasis, resulting from an imbalance between osteoblast-mediated bone formation and osteoclast-driven bone resorption. Emerging evidence implicates ferroptosis, an iron-dependent form of regulated cell death… read more here.
Keywords: bone; ferroptosis mediated; mediated osteoclast; osteoclast osteoblast ... See more keywords
Overexpression of Neurogenin 1 Negatively Regulates Osteoclast and Osteoblast Differentiation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126708
Abstract: Neurogenin 1 (Ngn1) belongs to the basic helix–loop–helix (bHLH) transcription factor family and plays important roles in specifying neuronal differentiation. The present study aimed to determine whether forced Ngn1 expression contributes to bone homeostasis. Ngn1… read more here.
Keywords: overexpression neurogenin; factor; differentiation; osteoblast differentiation ... See more keywords