Cell–substrate traction force regulates the fusion of osteoclast precursors through cell–cell interaction
Sign Up to like & getrecommendations! Published in 2019 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-019-01223-4
Abstract: The adhesion morphology of a cell monolayer results in a mechanical force inside cells, between cells, or between cells and substrates. The mechanical force regulates the differentiation of stem cells, but its influence on cell… read more here.
Keywords: substrate traction; cell substrate; force; osteoclast precursors ... See more keywords
Deletion of IL-17ra in osteoclast precursors increases bone mass by decreasing osteoclast precursor abundance.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116310
Abstract: Metabolic bone diseases, such as osteoporosis, typically reflect an increase in the number and activity of bone-resorbing osteoclasts that result in a loss of bone mass. Inflammatory mediators have been identified as drivers of both… read more here.
Keywords: bone; bone mass; 17ra osteoclast; osteoclast precursors ... See more keywords
Anti‐osteoclastogenesis of Mineral Trioxide Aggregate through Inhibition of the Autophagic Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Endodontics"
DOI: 10.1016/j.joen.2016.12.013
Abstract: Introduction: Mineral trioxide aggregate (MTA) regulates bone remodeling, particularly osteoclast differentiation. However, intracellular mechanisms underlying the anti‐osteoclastogenesis of MTA remain unclear. This study aimed to evaluate the potential alterations of autophagic pathway during anti‐osteoclastogenic effects… read more here.
Keywords: trioxide aggregate; autophagic pathway; mta; mta extracts ... See more keywords
Integrin &agr;M&bgr;2 is differently expressed by subsets of human osteoclast precursors and mediates adhesion of classical monocytes to bone
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2016.11.018
Abstract: Abstract Bone‐degrading osteoclasts are formed through fusion of their monocytic precursors. In the population of human peripheral blood monocytes, three distinct subsets have been identified: classical, intermediate and non‐classical monocytes. We have previously shown that… read more here.
Keywords: agr bgr; integrin agr; bone; osteoclast precursors ... See more keywords
Reactive oxygen species are required for zoledronic acid-induced apoptosis in osteoclast precursors and mature osteoclast-like cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44245
Abstract: Inhibiting osteoclasts and osteoclast precursors to reduce bone resorption is an important strategy to treat osteoclast-related diseases, such as osteoporosis, inflammatory bone loss, and malignant bone metastasis. However, the mechanism by which apoptosis is induced… read more here.
Keywords: apoptosis; like cells; osteoclast like; mature osteoclast ... See more keywords
Soluble Sema4D cleaved from osteoclast precursors by TACE suppresses osteoblastogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular and molecular medicine"
DOI: 10.1111/jcmm.17416
Abstract: Bone remodelling is mediated by orchestrated communication between osteoclasts and osteoblasts which, in part, is regulated by coupling and anti-coupling factors. Amongst formally known anti-coupling factors, Semaphorin 4D (Sema4D), produced by osteoclasts, plays a key… read more here.
Keywords: tace mab; tace; osteoclast precursors; anti tace ... See more keywords
IL4/IL4R signaling promotes the osteolysis in metastatic bone of CRC through regulating the proliferation of osteoclast precursors
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DOI: 10.1186/s10020-021-00411-2
Abstract: Background Bone metastasis of colorectal cancer (CRC) often indicates a poor prognosis. Osteolysis can be observed in metastatic sites, implying an aberrant activation of osteoclasts. However, how osteoclastogenesis is regulated in metastatic microenvironment caused by… read more here.
Keywords: bone; proliferation; il4 il4r; osteoclast precursors ... See more keywords
Conditioned medium from rat dental pulp reduces the number of osteoclasts via attenuation of adhesiveness in osteoclast precursors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of oral science"
DOI: 10.2334/josnusd.17-0342
Abstract: Dental pulp is known to play crucial roles in homeostasis of teeth and periodontal tissue. Although resorption of bone around the roots of nonvital teeth is occasionally observed in clinical practice, little is known about… read more here.
Keywords: conditioned medium; medium rat; number; osteoclast precursors ... See more keywords
RANK signaling in osteoclast precursors results in a more permissive epigenetic landscape and sexually divergent patterns of gene expression
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DOI: 10.7717/peerj.14814
Abstract: Background Sex is an important risk factor in the development of osteoporosis and other bone loss disorders, with women often demonstrating greater susceptibility than men. While variation in sex steroids, such as estradiol, accounts for… read more here.
Keywords: gene expression; sex; osteoclast precursors; seq ... See more keywords