MicroRNA‐1225 activates Keap1‐Nrf2‐HO‐1 signalling to inhibit TNFα‐induced osteoclastogenesis by mediating ROS generation
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3394
Abstract: The influence of miRNA‐1225‐5p (miR‐1225) and Keap1‐Nrf2 signalling on in vitro osteoclast differentiation in mouse models was studied along with the underlying mechanism. In differentiated bone marrow–derived macrophages (BMMs), downregulated miR‐1225 and upregulated Keap1 were… read more here.
Keywords: mir 1225; tnf; keap1 nrf2; ros generation ... See more keywords
Rab34 plays a critical role as a bidirectional regulator of osteoclastogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3691
Abstract: Accumulating evidence suggests that Rab GTPases representing the largest branch of Ras superfamily have recently emerged as the core factors for the regulation of osteoclastogenesis through modulating vesicular transport amongst specific subcellular compartments. Among these,… read more here.
Keywords: osteoclast differentiation; role; osteoclastogenesis; regulator ... See more keywords
Murine osteoclastogenesis suppression using conditioned media produced by melanoma or activated and non‐activated Jurkat‐E6 cells
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11317
Abstract: Conditioned medium (CM) (cell secretome) is a cocktail of growth factors, cytokines, and other soluble mediators secreted by cells into a culture medium. These growth factors are fundamental in many cellular processes such as cell… read more here.
Keywords: activated jurkat; jurkat cells; differentiation; cell ... See more keywords
LRP1 Suppresses Bone Resorption in Mice by Inhibiting the RANKL‐Stimulated NF‐κB and p38 Pathways During Osteoclastogenesis
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DOI: 10.1002/jbmr.3469
Abstract: Single‐nucleotide polymorphisms in the LRP1 gene coding sequence are associated with low bone mass, and cell culture studies suggest that LRP1 plays a role in osteoblast proliferation and osteoblast‐mediated osteoclastogenesis. However, the in vivo function… read more here.
Keywords: p38 pathways; lrp1; bone; mice ... See more keywords
CCN2 Facilitates IL‐17 Production and Osteoclastogenesis in Human Osteoarthritis Synovial Fibroblasts by Inhibiting miR‐655 Expression
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4661
Abstract: Osteoarthritis (OA) is associated with extensive upregulation of osteoclastogenesis and subsequent bone breakdown. The CCN family protein connective tissue growth factor (CCN2, also called CCN2) enhances inflammatory cytokine production in OA disease. The cytokine interleukin… read more here.
Keywords: osteoclastogenesis; mir 655; expression; production ... See more keywords
Suppressing angiogenesis regulates the irradiation‐induced stimulation on osteoclastogenesis in vitro
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DOI: 10.1002/jcp.26196
Abstract: Ionizing radiation‐induced bone loss is a potential health concern in radiotherapy, occupational exposure, and astronauts. Although impaired bone vasculature and reduced proliferation of bone‐forming osteoblasts has been implicated in this process, it has not been… read more here.
Keywords: irradiation; angiogenesis; irradiation induced; bone loss ... See more keywords
LncRNA AK077216 promotes RANKL‐induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27031
Abstract: Osteoclasts derived from the monocyte/macrophage hematopoietic lineage regulate bone resorption, a process balanced by bone formation in the continual renewal of the skeletal system. As dysfunctions of these cells result in bone metabolic diseases such… read more here.
Keywords: bone resorption; bone; expression; lnc ak077216 ... See more keywords
Chitooligosaccharide inhibits RANKL‐induced osteoclastogenesis and ligation‐induced periodontitis by suppressing MAPK/ c‐fos/NFATC1 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29207
Abstract: Considering the high rate of osteoclast‐related diseases worldwide, research targeting osteoclast formation/function is crucial. In vitro, we demonstrated that chitooligosaccharide (CS) dramatically inhibited osteoclastogenesis as well as osteoclast function dose‐dependently. CS suppressed osteoclast‐specific genes expression… read more here.
Keywords: induced osteoclastogenesis; mapk fos; fos nfatc1; rankl induced ... See more keywords
Fine-tuning osteoclastogenesis: An insight into the cellular and molecular regulation of osteoclastogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular physiology"
DOI: 10.1002/jcp.31036
Abstract: Osteoclasts, the bone-resorbing cells, are essential for the bone remodeling process and are involved in the pathophysiology of several bone-related diseases. The extensive corpus of in vitro research and crucial mouse model studies in the… read more here.
Keywords: osteoclastogenesis; molecular regulation; bone; fine tuning ... See more keywords
Mechanisms involved in normal and pathological osteoclastogenesis
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DOI: 10.1007/s00018-018-2817-9
Abstract: Osteoclasts are bone-resorbing cells that play an essential role in bone remodeling. Defects in osteoclasts result in unbalanced bone remodeling and are linked to many bone diseases including osteoporosis, rheumatoid arthritis, primary bone cancer, and… read more here.
Keywords: normal pathological; pathological osteoclastogenesis; bone; mechanisms involved ... See more keywords
Sclareol inhibits RANKL-induced osteoclastogenesis and promotes osteoblastogenesis through promoting CCN1 expression via repressing the MAPK pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology and toxicology"
DOI: 10.1007/s10565-020-09578-6
Abstract: Osteoclasts are crucial cellular components of bone and are the cause of various bone problems like osteoporosis. Various biological activities such as anti-tumorous, anti-inflammatory, antibacterial, and immunomodulatory function are influenced by Sclareol, as a natural… read more here.
Keywords: sclareol; mapk pathway; rankl induced; bone ... See more keywords