Fenugreek steroidal saponins hinder osteoclastogenic bone resorption by targeting CSF-1R which diminishes the RANKL/OPG ratio.
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DOI: 10.1016/j.ijbiomac.2021.06.197
Abstract: Osteoporosis is skeletal fragility caused by the excessive bone resorption due to osteoclastogenesis. But current drugs are less bioavailable and possess higher toxicity. Our study was conducted to identify safe oral bioavailable drugs from Fenugreek… read more here.
Keywords: steroidal saponins; fenugreek steroidal; bone resorption; osteoclastogenic bone ... See more keywords