Hindlimb unloading causes regional loading-dependent changes in osteocyte inflammatory cytokines that are modulated by exogenous irisin treatment.
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DOI: 10.1038/s41526-020-00118-4
Abstract: Disuse-induced bone loss is characterized by alterations in bone turnover. Accruing evidence suggests that osteocytes respond to inflammation and express and/or release pro-inflammatory cytokines; however, it remains largely unknown whether osteocyte inflammatory proteins are influenced… read more here.
Keywords: hindlimb; osteocyte inflammatory; exogenous irisin; inflammatory cytokines ... See more keywords