DNA Tetrahedron Delivering miR‐21‐5p Promotes Senescent Bone Defects Repair through Synergistic Regulation of Osteogenesis and Angiogenesis
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202401275
Abstract: Compromised osteogenesis and angiogenesis is the character of stem cell senescence, which brought difficulties for bone defects repairing in senescent microenvironment. As the most abundant bone‐related miRNA, miRNA‐21‐5p plays a crucial role in inducing osteogenic… read more here.
Keywords: senescent bone; osteogenesis angiogenesis; osteogenesis; tdn mir ... See more keywords
Osthole accelerates osteoporotic fracture healing by inducing the osteogenesis–angiogenesis coupling of BMSCs via the Wnt/β‐catenin pathway
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8267
Abstract: Osthole, a natural coumarin derivative, has been shown to have multiple pharmacological activities. However, its effect on osteoporotic fracture has not yet been examined. This research was designed to explore the unknown role and potential… read more here.
Keywords: osteogenesis angiogenesis; fracture healing; fracture; osteoporotic fracture ... See more keywords
An improved osseointegration of metal implants by pitavastatin loaded multilayer films with osteogenic and angiogenic properties.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.121260
Abstract: An increasing number of works have highlighted the importance of metal implants surface modification in enhancing bone defect healing through the synergistic osteogenesis-angiogenesis regulation. Studies have shown that pitavastatin has the effect of promoting osteogenesis… read more here.
Keywords: osteogenesis angiogenesis; pitavastatin; multilayer films; pitavastatin loaded ... See more keywords
Mechanism of dexmedetomidine regulating osteogenesis-angiogenesis coupling through the miR-361-5p/VEGFA axis in postmenopausal osteoporosis.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119273
Abstract: AIMS Postmenopausal osteoporosis (PMOP) is a growing health problem affecting many postmenopausal women. This study intended to identify the role of dexmedetomidine (Dex) on osteoporosis (OP). MAIN METHODS Microarray analysis was performed for the gene… read more here.
Keywords: angiogenesis; dex; mir 361; osteogenesis angiogenesis ... See more keywords
Engineering 3D-Printed Strontium-Titanium Scaffold-Integrated Highly Bioactive Serum Exosomes for Critical Bone Defects by Osteogenesis and Angiogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c00898
Abstract: Currently, healing of large bone defects faces significant challenges such as a bulk of bone regeneration and revascularization on the bone defect region. Here, a "cell-free scaffold engineering" strategy that integrates strontium (Sr) and highly… read more here.
Keywords: highly bioactive; bone; osteogenesis angiogenesis; scaffold ... See more keywords
Construction of Magnesium Phosphate Chemical Conversion Coatings with Different Microstructures on Titanium to Enhance Osteogenesis and Angiogenesis.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c03024
Abstract: Titanium (Ti) and its alloys are widely used as hard tissue substitutes in dentistry and orthopedics, but their low bioactivity leads to undesirable osseointegration defects in the early osteogenic phase. Surface modification is an important… read more here.
Keywords: magnesium phosphate; chemical conversion; osteogenesis; osteogenesis angiogenesis ... See more keywords
A metamaterial scaffold beyond modulus limits: enhanced osteogenesis and angiogenesis of critical bone defects
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-57609-9
Abstract: Metallic scaffolds have shown promise in regenerating critical bone defects. However, limitations persist in achieving a modulus below 100 MPa due to insufficient strength. Consequently, the osteogenic impact of lower modulus and greater bone tissue strain… read more here.
Keywords: critical bone; metamaterial scaffold; osteogenesis angiogenesis; bone ... See more keywords
Lithium and Copper Induce the Osteogenesis-Angiogenesis Coupling of Bone Marrow Mesenchymal Stem Cells via Crosstalk between Canonical Wnt and HIF-1α Signaling Pathways
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cells International"
DOI: 10.1155/2021/6662164
Abstract: The combination of osteogenesis and angiogenesis dual-delivery trace element-carrying bioactive scaffolds and stem cells is a promising method for bone regeneration and repair. Canonical Wnt and HIF-1α signaling pathways are vital for BMSCs' osteogenic differentiation… read more here.
Keywords: hif signaling; angiogenesis; canonical wnt; osteogenesis angiogenesis ... See more keywords
Notch Signaling Augments BMP9-Induced Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells (MSCs)
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000471945
Abstract: Background/Aims: Mesenchymal stem cells (MSCs) are multipotent progenitors that can differentiate into several lineages including bone. Successful bone formation requires osteogenesis and angiogenesis coupling of MSCs. Here, we investigate if simultaneous activation of BMP9 and… read more here.
Keywords: angiogenesis; bone formation; osteogenesis angiogenesis; bmp9 induced ... See more keywords
Endothelial cell-derived exosomes trigger a positive feedback loop in osteogenesis-angiogenesis coupling via up-regulating zinc finger and BTB domain containing 16 in bone marrow mesenchymal stem cell
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-024-03002-5
Abstract: The close spatial and temporal connection between osteogenesis and angiogenesis around type H vasculature is referred as “osteogenesis-angiogenesis coupling”, which is one of the basic mechanisms of osteogenesis. Endothelial cells (ECs), bone marrow mesenchymal stem… read more here.
Keywords: angiogenesis; osteogenesis angiogenesis; bone marrow; angiogenesis coupling ... See more keywords
Accelerated Bone Regeneration by Astragaloside IV through Stimulating the Coupling of Osteogenesis and Angiogenesis
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.57681
Abstract: Both osteoblasts and preosteoclasts contribute to the coupling of osteogenesis and angiogenesis, regulating bone regeneration. Astragaloside IV (AS-IV), a glycoside of cycloartane-type triterpene derived from the Chinese herb Astragalus membranaceus, exhibits various biological activities, including… read more here.
Keywords: angiogenesis; bone regeneration; osteogenesis angiogenesis; coupling osteogenesis ... See more keywords