ADAMTS7 degrades Comp to fuel BMP2‐dependent osteogenic differentiation and ameliorate oncogenic potential in osteosarcomas
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12939
Abstract: Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, with a high metastatic potential. Despite dramatic changes in OS treatments over the past decades, their efficiency still remains limited, with… read more here.
Keywords: adamts7 degrades; differentiation; osteogenic differentiation; comp fuel ... See more keywords
Efficient Single‐Dose Induction of Osteogenic Differentiation of Stem Cells Using Multi‐Bioactive Hybrid Nanocarriers
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DOI: 10.1002/adbi.202000123
Abstract: Bone regeneration requires the presence of specific factors to induce the differentiation of stem cells into osteoblasts. These factors induce osteogenesis by stimulating the expression of bone‐related proteins, bone cell proliferation and differentiation. Herein, bioactive… read more here.
Keywords: stem cells; differentiation; differentiation stem; osteogenic differentiation ... See more keywords
2D Covalent Organic Framework Direct Osteogenic Differentiation of Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202101737
Abstract: 2D covalent organic frameworks (COFs) are an emerging class of crystalline porous organic polymers with a wide‐range of potential applications. However, poor processability, aqueous instability, and low water dispersibility greatly limit their practical biomedical implementation.… read more here.
Keywords: osteogenic differentiation; cofs sustained; covalent organic; stem ... See more keywords
Transcriptomic Changes toward Osteogenic Differentiation of Mesenchymal Stem Cells on 3D‐Printed GelMA/CNC Hydrogel under Pulsatile Pressure Environment
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202163
Abstract: Biomimetic soft hydrogels used in bone tissue engineering frequently produce unsatisfactory outcomes. Here, it is investigated how human bone‐marrow‐derived mesenchymal stem cells (hBMSCs) differentiated into early osteoblasts on remarkably soft 3D hydrogel (70 ± 0.00049… read more here.
Keywords: osteogenic differentiation; pulsatile pressure; mesenchymal stem; stem ... See more keywords
High glucose impairs osteogenic differentiation of embryonic stem cells via early diversion of beta‐catenin from Forkhead box O to T cell factor interaction
Sign Up to like & getrecommendations! Published in 2022 at "Birth Defects Research"
DOI: 10.1002/bdr2.2085
Abstract: Diabetes, which is characterized by an increase in blood glucose concentration, is accompanied by low bone turnover, increased fracture risk, and the formation of embryonic skeletal malformations. Yet, there are few studies elucidating the underlying… read more here.
Keywords: beta catenin; high glucose; osteogenic differentiation;
MiR‐615‐3p inhibits the osteogenic differentiation of human lumbar ligamentum flavum cells via suppression of osteogenic regulators GDF5 and FOXO1
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology International"
DOI: 10.1002/cbin.10780
Abstract: Ossification of the ligamentum flavum (OLF) is a disease of heterotopic ossification in spinal ligaments. The key of the OLF pathogenesis is the differentiation of fibroblasts into osteoblasts. In this study, we explored the role… read more here.
Keywords: differentiation human; ligamentum flavum; differentiation; osteogenic differentiation ... See more keywords
MiRNA‐1271‐5p regulates osteogenic differentiation of human bone marrow‐derived mesenchymal stem cells by targeting forkhead box O1 (FOXO1)
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DOI: 10.1002/cbin.11585
Abstract: Forkhead box O1 (FOXO1) is a key regulator of osteogenesis. The aim of this study was to identify the mechanisms of microRNAs (miRNAs) targeting FOXO1 in osteogenic differentiation of human bone marrow mesenchymal stem cells… read more here.
Keywords: foxo1; bone; expression; osteogenic differentiation ... See more keywords
Human osteoprogenitor cells obtained from traumatic heterotopic ossification samples showed enhanced osteogenic differentiation potential and ERK/hedgehog signaling than that from normal bone
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2670
Abstract: Traumatic heterotopic ossification (HO) refers to the abnormal ectopic osteogenesis following trauma, causing limb dysfunction and seriously lowering the life quality of patients. Aberrant osteogenic behavior of progenitor cells that ectopically accumulated within the soft… read more here.
Keywords: hedgehog signaling; heterotopic ossification; osteogenic differentiation; hedgehog ... See more keywords
Galectin‐3 Enhances Osteogenic Differentiation of Precursor Cells From Patients With Diffuse Idiopathic Skeletal Hyperostosis via Wnt/β‐Catenin Signaling
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DOI: 10.1002/jbmr.4508
Abstract: Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory skeletal disease characterized by the progressive ectopic ossification and calcification of ligaments and enthuses. However, specific pathogenesis remains unknown. Bone marrow mesenchymal stem cells (BMSCs) are a… read more here.
Keywords: osteogenic differentiation; bmscs; dish bmscs; galectin ... See more keywords
Sprouty 2, an Early Response Gene Regulator of FosB and Mesenchymal Stem Cell Proliferation During Mechanical Loading and Osteogenic Differentiation
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DOI: 10.1002/jcb.26035
Abstract: Sprouty 2 (Spry2), an inhibitor of MAP kinase signaling was previously shown by our group to be induced during mechanical loading of mesenchymal stem cells (MSCs). Here, we studied the implication of Spry2 activation during… read more here.
Keywords: mechanical loading; osteogenic differentiation; early response; loading ... See more keywords
Inhibition of transforming growth factor‐β signaling pathway enhances the osteogenic differentiation of unrestricted somatic stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27209
Abstract: In recent years, extensive studies have been performed to enhance stem cell‐based therapies for bone and cartilage repair. Among various sources of stem cells, cord blood‐derived unrestricted somatic stem cells (USSCs) seem to be the… read more here.
Keywords: signaling pathway; stem cells; differentiation; osteogenic differentiation ... See more keywords