Abietic acid attenuates RANKL induced osteoclastogenesis and inflammation associated osteolysis by inhibiting the NF‐KB and MAPK signaling
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26575
Abstract: Osteoporosis is a major debilitating cause of fractures and decreases the quality of life in elderly patients. Bone homeostasis is maintained by bone forming osteoblasts and bone resorpting osteoclasts. Substantial evidences have shown that targeting… read more here.
Keywords: induced osteoclastogenesis; rankl induced; mapk signaling; osteolysis ... See more keywords
Daphnetin attenuates LPS‐induced osteolysis and RANKL mediated osteoclastogenesis through suppression of ERK and NFATc1 pathways
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28408
Abstract: Aseptic prosthetic loosening and periprosthetic infection resulting in inflammatory osteolysis is a leading complication of total joint arthroplasty (TJA). Excessive bone destruction around the bone and prosthesis interface plays a key role in the loosening… read more here.
Keywords: daphnetin; bone; erk nfatc1; osteolysis ... See more keywords
Protective effect of zinc supplementation on tricalcium phosphate particles‐induced inflammatory osteolysis in mice
Sign Up to like & getrecommendations! Published in 2022 at "Microscopy Research and Technique"
DOI: 10.1002/jemt.24213
Abstract: Zinc (Zn), an essential trace element, can stimulate bone formation and inhibit osteoclastic bone resorption, which controls the growth and maintenance of bone. However, the effect of Zn supplementation on tricalcium phosphate (TCP) wear particles‐induced… read more here.
Keywords: osteolysis; bone; supplementation tricalcium; tcp particles ... See more keywords
Expression of XBP1s in fibroblasts is critical for TiAl6V4 particle‐induced RANKL expression and osteolysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.23056
Abstract: Wear particle‐induced osteolysis is a major cause of aseptic loosening, which is one of the most common reasons for total hip arthroplasty (THA) failure. Previous studies have shown that the expression of Receptor activation of… read more here.
Keywords: xbp1s; particle induced; osteolysis; expression ... See more keywords
Periimplant osteolysis does not affect the outcome of rotator cuff repair: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "Knee Surgery, Sports Traumatology, Arthroscopy"
DOI: 10.1007/s00167-020-06328-3
Abstract: The goal of this study was to perform a systematic review and meta-analysis to compare the clinical and radiologic outcomes of rotator cuff repair, depending on the presence of developed periimplant osteolysis (PIO) after using… read more here.
Keywords: rotator cuff; analysis; periimplant osteolysis; osteolysis ... See more keywords
Osteolysis after cervical disc arthroplasty with artificial cervical disc
Sign Up to like & getrecommendations! Published in 2024 at "European Spine Journal"
DOI: 10.1007/s00586-024-08585-z
Abstract: Cervical total disc arthroplasty (TDA) is a motion-preserving alternative to anterior cervical discectomy and fusion that has gained popularity among spine surgeons. Although generally effective, TDA has been associated with rare cases of progressive osteolysis,… read more here.
Keywords: disc arthroplasty; osteolysis; artificial cervical; disc ... See more keywords
Ghrelin Fights Against Titanium Particle-Induced Inflammatory Osteolysis Through Activation of β-Catenin Signaling Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation"
DOI: 10.1007/s10753-019-01026-w
Abstract: Aseptic loosening is a major complication of prosthetic joint surgery, in which exaggerated inflammation and impaired osteoblastogenesis are detected. Ghrelin is a recently discovered neuropeptide that is closely associated with inflammatory conditions and bone regeneration.… read more here.
Keywords: titanium particle; catenin signaling; particle induced; titanium ... See more keywords
Transcriptional profile of human macrophages stimulated by ultra-high molecular weight polyethylene particulate debris of orthopedic implants uncovers a common gene expression signature of rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.11.001
Abstract: Osteolysis is a serious postoperative complication of total joint arthroplasty that leads to aseptic loosening and surgical revision. Osteolysis is a chronic destructive process that occurs when host macrophages recognize implant particles and release inflammatory… read more here.
Keywords: pathogenesis osteolysis; gene expression; ultra high; osteolysis ... See more keywords
Pulsed electromagnetic fields and platelet rich plasma alone and combined for the treatment of wear-mediated periprosthetic osteolysis: An in vivo study.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.07.012
Abstract: Wear-mediated osteolysis is a common complication occurring around implanted prosthesis, which ultimately leads to bone loss with mechanical instability and the need for surgical revision. At the moment, revision surgery is the only effective treatment.… read more here.
Keywords: vivo; treatment; bone; osteolysis ... See more keywords
Osteocytes respond to particles of clinically-relevant conventional and cross-linked polyethylene and metal alloys by up-regulation of resorptive and inflammatory pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.01.047
Abstract: Periprosthetic osteolysis is a major cause of implant failure in total hip replacements. Aseptic loosening caused by osteolytic lesions is associated with the production of bioactive wear particles from the articulations of implants. Wear particles… read more here.
Keywords: metal alloys; cross linked; metal; osteolysis ... See more keywords
Zinc alloy-based bone internal fixation screw with antibacterial and anti-osteolytic properties
Sign Up to like & getrecommendations! Published in 2021 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2021.05.023
Abstract: There is no targeted effective treatment for patients undergoing internal fixation surgery/two-stage total joint revision surgery with a high risk of postoperative infection and osteolysis, while the rate of reoperation due to infection and osteolysis… read more here.
Keywords: antibacterial anti; fixation; osteolytic properties; osteolysis ... See more keywords