Ameliorating Effect of Osteopontin on H2O2-Induced Apoptosis of Human Oligodendrocyte Progenitor Cells
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0563-4
Abstract: Recently our group used oligodendrocyte progenitor cells (OPCs) as appropriate model cells to pinpoint the mechanism of the progress of neurodegenerative disorders. In the present study, we focused on the therapeutic role of osteopontin (OPN),… read more here.
Keywords: progenitor cells; osteopontin; apoptosis; h2o2 ... See more keywords
Plasma osteopontin levels in patients with acute kidney injury requiring dialysis: a study in a tertiary care institute in South India
Sign Up to like & getrecommendations! Published in 2020 at "International Urology and Nephrology"
DOI: 10.1007/s11255-020-02417-x
Abstract: Purpose Osteopontin (OPN) is evolving as a novel biomarker of injury, overall survival and renal outcome in critically ill patients with acute kidney injury (AKI), requiring renal replacement therapy. Methods We performed a prospective study… read more here.
Keywords: kidney injury; osteopontin; injury requiring; patients acute ... See more keywords
Osteopontin exacerbates Pseudomonas aeruginosa-induced bacteremia in mice.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2017.05.004
Abstract: Osteopontin (OPN) is a multifunctional protein involved in various pathophysiological processes. However, the role of OPN in Pseudomonas aeruginosa-related sepsis is not yet clear. Here, we found that OPN expression was elevated in plasma and… read more here.
Keywords: aeruginosa induced; pseudomonas aeruginosa; induced bacteremia; osteopontin ... See more keywords
A0812 Osteopontin associated with cardiac target organ damage in essential hypertension
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548421.51602.92
Abstract: Objectives: To investigate the relationship between circulating osteopontin (OPN) and left ventricular (LV) geometry, as well as systolic and diastolic function in patients with essential hypertension. Methods: 199 essential hypertensive patients were recruited (mean age… read more here.
Keywords: low opn; osteopontin; hypertension; opn group ... See more keywords
Thrombin cleavage of osteopontin initiates osteopontin’s tumor‐promoting activity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15663
Abstract: Osteopontin (OPN) is a multifunctional proinflammatory matricellular protein overexpressed in multiple human cancers and associated with tumor progression and metastases. Thrombin cleavage of OPN reveals a cryptic binding site for α4β1 and α9β1 integrins. read more here.
Keywords: cleavage osteopontin; osteopontin; osteopontin initiates; tumor ... See more keywords
Abstract 4147: Role of MLK3-mediated phosphorylation of β-catenin in regulating cellular senescence and osteopontin expression in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4147
Abstract: The canonical Wnt/β-catenin signaling pathway is important for normal liver growth and development, abnormal activation of which can lead to various liver pathologies, including hepatocellular carcinoma (HCC). Usually, β-catenin signaling is regulated by a degradation… read more here.
Keywords: senescence; phosphorylation; hcc; catenin ... See more keywords
Intracellular Osteopontin of Macrophages Promotes Carotid Plaques Formation by Inducing Foam Cells and Releasing Proinflammatory Cytokines.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Heart Association"
DOI: 10.1161/jaha.125.041336
Abstract: BACKGROUND Atherosclerotic carotid plaque is the main cause of cerebrovascular diseases, but the molecular and cellular mechanisms involving in carotid plaque formation have not yet been fully uncovered. METHODS Single cell RNA sequencing of human… read more here.
Keywords: plaque; cell; foam cells; osteopontin ... See more keywords
CSF TNF and osteopontin levels correlate with the response to dimethyl fumarate in early multiple sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Advances in Neurological Disorders"
DOI: 10.1177/17562864221092124
Abstract: Background: Disease activity in the first years after a diagnosis of relapsing-remitting multiple sclerosis (RRMS) is a negative prognostic factor for long-term disability. Markers of both clinical and radiological responses to disease-modifying therapies (DMTs) are… read more here.
Keywords: csf; disease activity; factor; activity ... See more keywords
Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01949-4
Abstract: Background Osteopontin (OPN) as a secreted signaling protein is dramatically induced in response to cellular injury and neurodegeneration. Microglial inflammatory responses in the brain are tightly associated with the neuropathologic hallmarks of neurodegenerative disease, but… read more here.
Keywords: brake regulating; response; osteopontin; infection ... See more keywords
A Reversed-Phase HPLC Method for Determination of Osteopontin in Infant Formula
Sign Up to like & getrecommendations! Published in 2019 at "Applied Sciences"
DOI: 10.3390/app9183711
Abstract: Osteopontin (OPN) is a multifunctional whey protein which has recently received much attention for possibly applications in fortifying infant milk formula (IMF) with its bioactivity. However, to date, there is no established high-performance liquid chromatography… read more here.
Keywords: reversed phase; osteopontin; method; phase hplc ... See more keywords
Prevention of Initial Bacterial Attachment by Osteopontin and Other Bioactive Milk Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10081922
Abstract: A considerable body of work has studied the involvement of osteopontin (OPN) in human physiology and pathology, but comparably little is known about the interaction of OPN with prokaryotic cells. Recently, bovine milk OPN has… read more here.
Keywords: milk proteins; bioactive milk; osteopontin; milk ... See more keywords