Interplay Between Long Noncoding RNA ZEB1‐AS1 and miR‐200s Regulates Osteosarcoma Cell Proliferation and Migration
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25879
Abstract: In our previous study, we found long noncoding RNA ZEB1‐AS1 is upregulated and functions as an oncogene in osteosarcoma. MiR‐200 family (miR‐200s) functions as tumor suppressor via directly targeting ZEB1 in various cancers. In this… read more here.
Keywords: as1 mir; mir 200s; zeb1 as1; zeb1 ... See more keywords
Betulin inhibits mTOR and induces autophagy to promote apoptosis in human osteosarcoma cell lines
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Toxicology"
DOI: 10.1002/tox.22924
Abstract: Betulin is a lupane type pentacyclic triterpenoid, and commonly found in the bark of birch trees. It displays various pharmacological properties, such as antibacterial, anti‐inflammation, antitumor, and antiviral. In this report, we attempted to investigate… read more here.
Keywords: cell lines; mtor; osteosarcoma cell; betulin ... See more keywords
Acute generation of reactive oxygen species that induced by doxycycline pretreatment results in rapid cell death in polyphyllin G‐treated osteosarcoma cell lines
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23757
Abstract: Polyphyllin G, a pennogenyl saponin extracted from Paris polyphylla, has been shown to possess antitumor effects. In this study, we demonstrated that doxycycline, an antibiotic medicine, could significantly enhance the sensitivities of osteosarcoma cell lines… read more here.
Keywords: cell death; cell; osteosarcoma cell; polyphyllin ... See more keywords
Baicalin induces apoptosis in human osteosarcoma cell through ROS-mediated mitochondrial pathway
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Research"
DOI: 10.1080/14786419.2017.1359173
Abstract: Abstract Baicalin is extracted from a traditional Chinese herb, Scutellaria baicalensis. In this study, the anticancer activity and underlying mechanisms of baicalin towards human osteosarcoma cell (HOS) were investigated. Baicalin could inhibit HOS cell proliferation… read more here.
Keywords: baicalin; osteosarcoma cell; apoptosis human; cell ... See more keywords
Elucidating the mechanisms of action of parecoxib in the MG-63 osteosarcoma cell line
Sign Up to like & getrecommendations! Published in 2020 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000000901
Abstract: Different types of tumors often present an overexpression of cyclooxygenase-2. The aim of this study was to evaluate the effects of parecoxib (NSAID, cyclooxygenase-2 selective inhibitor) in the behavior of the human osteosarcoma MG-63 cell… read more here.
Keywords: cell line; parecoxib; osteosarcoma cell; cell ... See more keywords
Characterization of five newly derived canine osteosarcoma cell lines
Sign Up to like & getrecommendations! Published in 2019 at "BMC Veterinary Research"
DOI: 10.1186/s12917-019-2099-y
Abstract: BackgroundCanine and human osteosarcomas (OS) are notably similar and have a high rate of metastasis. There is a poor understanding of the tumor development process, predisposing causes, and varying levels of aggression among different cell… read more here.
Keywords: canine osteosarcoma; cell lines; cell; osteosarcoma cell ... See more keywords
Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0171256
Abstract: Osteosarcomas are malignant tumors of bone, most commonly seen in children and adolescents. Despite advances in modern medicine, the poor survival rate of metastatic osteosarcoma has not improved in two decades. In the present study… read more here.
Keywords: lm7 cells; osteosarcoma; proliferation; proliferation survival ... See more keywords
Overendocytosis of superparamagnetic iron oxide particles increases apoptosis and triggers autophagic cell death in human osteosarcoma cell under a spinning magnetic field
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14114
Abstract: The toxicity of superparamagnetic iron oxide nanoparticles (SPIONs) is still a vital topic of debate and the mechanisms remain unclear. In the present study, overdose SPIONs could induce osteosarcoma cell death and the effects were… read more here.
Keywords: iron oxide; spinning magnetic; superparamagnetic iron; cell death ... See more keywords
METTL14 Overexpression Promotes Osteosarcoma Cell Apoptosis and Slows Tumor Progression via Caspase 3 Activation
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Management and Research"
DOI: 10.2147/cmar.s284273
Abstract: Background As a key enzyme of m6A methylation modification, methyltransferase-like 14 (METTL14) is involved in many physiological and pathophysiological processes. This study aims to explore the effect of METTL14 on the viability of osteosarcoma cells… read more here.
Keywords: cell apoptosis; mettl14; osteosarcoma cell; osteosarcoma ... See more keywords
MiR-582-5p inhibits the growth and invasion of osteosarcoma cell by targeting NOVA1.
Sign Up to like & getrecommendations! Published in 2020 at "European Review for Medical and Pharmacological Sciences"
DOI: 10.26355/eurrev_202011_23587
Abstract: Objective To investigate the role of microRNA-582-5p (miR-582-5p) on osteosarcoma (OS) cell behaviors and provide potential therapeutic targets for OS. Materials and methods Expression levels of miR-582-5p in OS cell lines and normal cell lines… read more here.
Keywords: mir 582; 582 inhibits; osteosarcoma cell; invasion ... See more keywords
Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2018.00470
Abstract: Biglycan, a small leucine rich proteoglycan (SLRP), is an important participant in bone homeostasis and development as well as in bone pathology. In the present study biglycan was identified as a positive regulator of MG63… read more here.
Keywords: catenin; cell growth; mg63 osteosarcoma; osteosarcoma cell ... See more keywords