Genomic Complexity of Osteosarcoma and Its Implication for Preclinical and Clinical Targeted Therapies.
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DOI: 10.1007/978-3-030-43085-6_1
Abstract: Osteosarcoma is a genomically complex disease characterized by few recurrent single-nucleotide mutations or in-frame fusions. In contrast, structural alterations, including copy number changes, chromothripsis, kataegis, loss of heterozygosity (LOH), and other large-scale genomic alterations, are… read more here.
Keywords: complexity osteosarcoma; genomic complexity; osteosarcoma implication; targeted therapies ... See more keywords