Cytoplasmic APE1 promotes resistance response in osteosarcoma patients with cisplatin treatment
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3461
Abstract: Chemotherapy resistance has become a hold back and major clinical challenge in osteosarcoma cancer. The alteration and subcellular distribution of apurinic/apyrimidinic endonuclease 1 (APE1) has been reported to be involved in chemotherapy resistance in many… read more here.
Keywords: chemotherapy; treatment; ape1; cytoplasmic ape1 ... See more keywords
FAT1 and MSH2 Are Predictive Prognostic Markers for Chinese Osteosarcoma Patients Following Chemotherapeutic Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4545
Abstract: Osteosarcoma is characterized by diverse genetic mutations, including single‐nucleotide variants (SNVs), which can complicate clinical outcomes of the treatment. This study identified key mutations or polymorphisms in genes that correlate with osteosarcoma prognoses. A total… read more here.
Keywords: chemotherapeutic treatment; fat1 msh2; prognosis; treatment ... See more keywords
In vitro drug sensitivity (IDS) of patient-derived primary osteosarcoma cells as an early predictor of the clinical outcomes of osteosarcoma patients
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-020-04081-5
Abstract: Purpose Early prediction of clinical response to conventional chemotherapy is a significant factor in determining an overall treatment strategy for osteosarcoma. Methods Cells were extracted from treatment-naïve biopsies from 16 osteosarcoma patients who received a… read more here.
Keywords: clinical outcomes; sensitivity ids; vitro drug; primary osteosarcoma ... See more keywords
Downregulation of serum miR-194 predicts poor prognosis in osteosarcoma patients.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2020.151488
Abstract: BACKGROUND Circulating microRNAs (miRNAs) have promising potential as diagnostic and prognostic biomarkers for osteosarcoma. This study aimed to explore the expression pattern of serum miR-194 and its potential clinical value in patients with osteosarcoma. METHODS… read more here.
Keywords: osteosarcoma patients; prognosis osteosarcoma; serum mir; mir 194 ... See more keywords
Pazopanib in relapsed osteosarcoma patients: report on 15 cases
Sign Up to like & getrecommendations! Published in 2019 at "Acta Oncologica"
DOI: 10.1080/0284186x.2018.1503714
Abstract: Osteosarcoma is a rare bone tumor that occurs in young adults with a subsequent peak in the fifth decade. Neoadjuvant and adjuvant chemotherapy and surgery cure approximately 60% of patients with l... read more here.
Keywords: patients report; report cases; osteosarcoma patients; pazopanib relapsed ... See more keywords
Evidence of Interleukin 21 Reduction in Osteosarcoma Patients Due to PD-1/PD-L1-Mediated Suppression of Follicular Helper T Cell Functionality.
Sign Up to like & getrecommendations! Published in 2017 at "DNA and cell biology"
DOI: 10.1089/dna.2017.3669
Abstract: Interleukin 21 (IL-21) is crucial for the development of a robust CD8+ T cell response and has been shown to promote antitumor immunity. Despite the fact that osteosarcoma presents significant genetic instability with a high… read more here.
Keywords: osteosarcoma patients; cell; follicular helper; tfh cells ... See more keywords
A DNA methylation-associated nomogram predicts the overall survival of osteosarcoma
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000023772
Abstract: Supplemental Digital Content is available in the text Abstract Numerous reports have demonstrated that DNA methylation may be underlying prognostic biomarkers of cancer. However, few studies indicated that DNA methylation was independent biomarker for osteosarcoma… read more here.
Keywords: methylation; osteosarcoma patients; dna methylation; methylation associated ... See more keywords
SIX4 upregulates IDH1 and metabolic reprogramming to promote osteosarcoma progression
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17650
Abstract: Metabolism reprogramming plays an important role in tumorigenesis and osteosarcoma metastasis. Sine oculis homeobox 4 (SIX4) is reported to be a key transcription factor that is involved in glycolysis reprogramming of cancer cells. However, the… read more here.
Keywords: osteosarcoma patients; six4; six4 upregulates; osteosarcoma progression ... See more keywords
Identification of Key Genes and miRNAs in Osteosarcoma Patients with Chemoresistance by Bioinformatics Analysis
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/4761064
Abstract: Chemoresistance is a significant factor associated with poor outcomes of osteosarcoma patients. The present study aims to identify Chemoresistance-regulated gene signatures and microRNAs (miRNAs) in Gene Expression Omnibus (GEO) database. The results of Gene Ontology… read more here.
Keywords: chemoresistance; identification key; analysis; genes mirnas ... See more keywords
Identification of ATG7 as a Regulator of Proferroptosis and Oxidative Stress in Osteosarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/8441676
Abstract: Background Ferroptosis has gained significant attention from oncologists as a vital outcome of oxidative stress. The aim of this study was to develop a prognostic signature that was based on the ferroptosis-related genes (FRGs) for… read more here.
Keywords: stress; signature; oxidative stress; osteosarcoma patients ... See more keywords
A Survival Status Classification Model for Osteosarcoma Patients Based on E-CNN-SVM and Multisource Data Fusion
Sign Up to like & getrecommendations! Published in 2022 at "Computational Intelligence and Neuroscience"
DOI: 10.1155/2022/9464182
Abstract: Traditional algorithms have the following drawbacks: (1) they only focus on a certain aspect of genetic data or local feature data of osteosarcoma patients, and the extracted feature information is not considered as a whole;… read more here.
Keywords: classification; osteosarcoma patients; survival status; model ... See more keywords