Silencing circUSP48 suppresses osteosarcoma progression by regulating the miR‐335/ smad nuclear interacting protein 1 pathway
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24828
Abstract: Circular RNAs (circRNAs) can have a critical function in the multi‐processes of osteosarcoma (OS). Nevertheless, whether circUSP48 is involved in OS progression remains unclear. read more here.
Keywords: silencing circusp48; progression; suppresses osteosarcoma; circusp48 ... See more keywords
Mesenchymal stroma: Role in osteosarcoma progression.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.07.024
Abstract: The initiation and progression of malignant tumors are supported by their microenvironment: cancer cells per se cannot explain growth and formation of the primary or metastasis, and a combination of proliferating tumor cells, cancer stem… read more here.
Keywords: progression; role; cancer; osteosarcoma progression ... See more keywords
TGF-β is associated with poor prognosis and promotes osteosarcoma progression via PI3K/Akt pathway activation
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2020.1805552
Abstract: ABSTRACT Transforming growth factor beta (TGF-β) is a multifunctional cytokine with important functions in cell proliferation and differentiation. TGF-β is highly expressed in several types of cancers and promotes tumor invasion and metastasis. However, the… read more here.
Keywords: osteosarcoma progression; tgf; pi3k; tgf associated ... See more keywords
RNA‐binding protein PUM2 suppresses osteosarcoma progression via partly and competitively binding to STARD13 3′UTR with miRNAs
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DOI: 10.1111/cpr.12508
Abstract: This work aims to reveal the roles and related mechanisms of RNA binding protein PUM2 in osteosarcoma progression. read more here.
Keywords: protein pum2; osteosarcoma progression; rna binding; binding protein ... See more keywords
SIX4 upregulates IDH1 and metabolic reprogramming to promote osteosarcoma progression
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17650
Abstract: Metabolism reprogramming plays an important role in tumorigenesis and osteosarcoma metastasis. Sine oculis homeobox 4 (SIX4) is reported to be a key transcription factor that is involved in glycolysis reprogramming of cancer cells. However, the… read more here.
Keywords: osteosarcoma patients; six4; six4 upregulates; osteosarcoma progression ... See more keywords
NFIL3 Acts as a Nuclear Factor to Increase Osteosarcoma Progression
Sign Up to like & getrecommendations! Published in 2019 at "BioMed Research International"
DOI: 10.1155/2019/4068521
Abstract: Purpose Osteosarcoma is one of the most common primary malignant, aggressive bone neoplasms. However, the mechanisms of osteosarcoma proliferation, migration, and invasion are not well understood. To explore the possible mechanism of osteosarcoma progression, we… read more here.
Keywords: osteosarcoma progression; migration invasion; osteosarcoma; proliferation ... See more keywords
UHRF1 associated with osteogenic differentiation of MSCs contributes to osteosarcoma progression and has clinical prognostic impact in osteosarcoma.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in eukaryotic gene expression"
DOI: 10.1615/critreveukaryotgeneexpr.2021041503
Abstract: Ubiquitin-like with plant homeodomain and ring finger domains 1 (UHRF1) can mediate DNA methylation and histone modifications in the epigenetic regulation of gene expression, stem cell differentiation and tumorigenesis. Here, we analyzed the differentially expressed… read more here.
Keywords: differentiation; differentiation mscs; osteosarcoma progression; osteosarcoma ... See more keywords
DJ-1 promotes osteosarcoma progression through activating CDK4/RB/E2F1 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1036401
Abstract: Osteosarcoma (OS) is a primary malignant tumor of the bone characterized by poor prognosis due to chemotherapy resistance and high recurrence rates. DJ-1 (PARK7) is known as an oncogene and its abnormal expression is related… read more here.
Keywords: progression; promotes osteosarcoma; cdk4 e2f1; activating cdk4 ... See more keywords
Silencing circOMA1 Inhibits Osteosarcoma Progression by Sponging miR-1294 to Regulate c-Myc Expression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.889583
Abstract: Background Several studies have reported that circRNAs have a crucial function in the tumorigenesis of various cancers. However, the expression and function of circOMA1 in osteosarcoma is unknown. Methods circOMA1 was identified through bioinformatics analysis.… read more here.
Keywords: circoma1; mir 1294; osteosarcoma progression; myc ... See more keywords
CircDOCK1 Regulates miR-186/DNMT3A to Promote Osteosarcoma Progression
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10123013
Abstract: Background: Circular RNAs (circRNAs), as a class of endogenous RNAs, are implicated in osteosarcoma (OS) progression. However, the functional properties of circDOCK1 in OS have been largely unexplored. The present study demonstrated the regulatory mechanism… read more here.
Keywords: progression; circdock1 regulates; 186 dnmt3a; mir 186 ... See more keywords