Conditional loss of IKKα in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-08914-6
Abstract: NF-κB has been reported to both promote and inhibit bone formation. To explore its role in osteolineage cells, we conditionally deleted IKKα, an upstream kinase required for non-canonical NF-κB activation, using Osterix (Osx)-Cre. Surprisingly, we… read more here.
Keywords: age; bone; cko mice; osx cre ... See more keywords
TGF-β Signaling Contributes to Myelofibrosis and Clonal Dominance of Myeloproliferative Neoplasms
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DOI: 10.1182/blood-2019-128943
Abstract: TGF-β expression is elevated in most cases of myeloproliferative neoplasms (MPNs). However, the contribution of TGF-β to disease pathogenesis is not well understood. Prior studies have shown that TGF-β regulates hematopoietic stem cell (HSC) quiescence.… read more here.
Keywords: expression; osx cre; tgf signaling; tgfbr2f ... See more keywords