Phosphine oxide-Sc(OTf)3 catalyzed enantioselective bromoaminocyclization of tri-substituted allyl N-tosylcarbamates
Sign Up to like & getrecommendations! Published in 2018 at "Science China Chemistry"
DOI: 10.1007/s11426-017-9192-x
Abstract: Phosphine oxide-Sc(OTf)3 catalyzed regio- and enantioselective bromoaminocyclization of tri-substituted allyl N-tosylcarbamates is described. A wide variety of optically active tertiary 5-bromo-1,3-oxazinan-2-ones can be obtained with high regio-and enantioselectivity. read more here.
Keywords: phosphine oxide; otf catalyzed; tri substituted; bromoaminocyclization tri ... See more keywords
Al(OTf)3-catalyzed one-pot synthesis of pyrrolo[3,2-d]pyrimidinedione derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.06.039
Abstract: Abstract A series of polysubstituted pyrrolo[3,2-d]pyrimidinedione derivatives have been synthesized in excellent yields. This prominent scaffold is obtained via an Al(OTf)3-catalyzed tandem addition-annulation sequence between propargylic alcohols and aminopyrimidines. The process is simple, facile, inexpensive,… read more here.
Keywords: pyrimidinedione derivatives; otf catalyzed; catalyzed one; pyrrolo pyrimidinedione ... See more keywords
Zn(OTf)2-catalyzed, microwave-promoted synthesis of 2-substituted 5-methyloxazoles from propargylic amides
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DOI: 10.1016/j.tetlet.2019.02.011
Abstract: Abstract The versatile conversion of propargylic amides to the respective 2-substituted 5-methyloxazoles was efficiently catalyzed by Zn(OTf)2 (5 mol%) under microwave irradiation in toluene. The method was applicable to a wide range of aliphatic, aromatic and… read more here.
Keywords: catalyzed microwave; substituted methyloxazoles; otf catalyzed; propargylic amides ... See more keywords
In(OTf)3-Catalyzed Synthesis of 2,3-Dihydro-1H-benzo[e]indoles and 2,3-Dihydrobenzofurans via [3 + 2] Annulation.
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DOI: 10.1021/acs.orglett.0c02729
Abstract: An In(OTf)3-catalyzed intermolecular [3 + 2] annulation for the synthesis of 2,3-dihydro-1H-benzo[e]indoles and 2,3-dihydrobenzofurans from readily available substrates has been achieved. This approach takes advantage of oxetane and para-quinone methide as important functional units in… read more here.
Keywords: indoles dihydrobenzofurans; otf catalyzed; annulation; benzo indoles ... See more keywords
A Cu(OTf)2-Catalyzed Glycosylation with Glycosyl ortho-N-Phthalimidoylpropynyl Benzoates as Donors.
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DOI: 10.1021/acs.orglett.3c01163
Abstract: A Cu(OTf)2-catalyzed glycosylation protocol using glycosyl ortho-N-phthalimidoylpropynyl benzoates (NPPBs) as donors was disclosed, which features an inexpensive copper catalyst, operationally convenient conditions, high to excellent yields, and a broad substrate scope. Mechanistic studies indicated an… read more here.
Keywords: catalyzed glycosylation; otf catalyzed; glycosyl ortho; phthalimidoylpropynyl benzoates ... See more keywords
In(OTf)3-Catalyzed Cascade Cyclization for Construction of Oxatricyclic Compounds.
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DOI: 10.1021/acs.orglett.8b03461
Abstract: A highly diastereoselective cascade cyclization reaction has been developed for establishing a series of oxatricyclic compounds using Chan's diene and simple keto alkynal substrates with only 1 mol % of In(OTf)3 as the catalyst in… read more here.
Keywords: otf catalyzed; cascade cyclization; construction; oxatricyclic compounds ... See more keywords
Cu(OTf)2 catalyzed Ugi-type reaction of N,O-acetals with isocyanides for the synthesis of pyrrolidinyl and piperidinyl 2-carboxamides.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc03113a
Abstract: The Cu(OTf)2 catalyzed Ugi-type reactions of N,O-acetals with isocyanides have been described for the synthesis of pyrrolidinyl and piperidinyl 2-carboxamides. 4-Hydroxy-5-substituted-prolinamides can be obtained in high diastereoselectivities (2,4-cis/trans > 19 : 1) and a stereoselective model was… read more here.
Keywords: otf catalyzed; catalyzed ugi; ugi type; pyrrolidinyl piperidinyl ... See more keywords
Sc(OTf)3 catalyzed [3 + 2]-annulation reaction of donor–acceptor aziridines with methylene exo-glycals: synthesis of chiral carbohydrate-spiro-heterocycles
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DOI: 10.1039/d1qo00228g
Abstract: A Sc(OTf)3 catalyzed [3 + 2]-annulation reaction between donor–acceptor aziridines and several exo-glycals has been developed. Using this method, some exo-glycals derived from D-ribose, D-galactose and uridine can be converted into carbohydrate-spiro-heterocycles easily in good… read more here.
Keywords: annulation reaction; catalyzed annulation; reaction; reaction donor ... See more keywords
Diastereoselective synthesis of tetrahydrobenzo[b]azocines by Lu(OTf)3-catalyzed [4+4] cycloaddition of donor-acceptor cyclobutanes with anthranils.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00829g
Abstract: The construction of N-heterocyclic eight-membered rings remains challenging due to unfavorable transannular strain. Herein, we report a Lu(OTf)3-catalyzed formal [4+4] cycloaddition reaction of cyclobutane 1,1-diesters with anthranils to deliver oxa-bridged eight-membered heterocycles. This methodology provides… read more here.
Keywords: diastereoselective synthesis; otf catalyzed; tetrahydrobenzo azocines; azocines otf ... See more keywords
Synthesis of 1,4-benzoxazines via Y(OTf)3-catalyzed ring opening/annulation cascade reaction of benzoxazoles with propargylic alcohols.
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DOI: 10.1039/d2cc03080b
Abstract: A convenient Y(OTf)3-catalyzed cascade formal [4 + 2] cyclization approach for the formation of 1,4-benzoxazine scaffolds from benzoxazoles and propargyl alcohols through a ring-opening and regioselective ring-closure process has been developed. By using this mild… read more here.
Keywords: otf catalyzed; benzoxazines via; via otf; synthesis benzoxazines ... See more keywords
Synthesis of 4-aryl-3,4-dihydrocoumarins and 4-aryl-4H-chromenes via Er(OTf)3-catalyzed cascade reactions of p-quinone methides with 1,3-dicarbonyl compounds
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DOI: 10.1039/d3ra02267f
Abstract: The Er(OTf)3-catalyzed cascade cyclization reaction of para-quinone methides (p-QMs) with various 1,3-dicarbonyl compounds has been developed, which efficiently constructed a series of versatile 4-aryl-3,4-dihydrocoumarins and 4-aryl-4H-chromenes. Herein, we not only propose a novel cyclization strategy… read more here.
Keywords: otf catalyzed; dihydrocoumarins aryl; catalyzed cascade; quinone methides ... See more keywords