Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202406473
Abstract: Candidiasis, which presents a substantial risk to human well‐being, is frequently treated with azoles. However, drug‐drug interactions caused by azoles inhibiting the human CYP3A4 enzyme, together with increasing resistance of Candida species to azoles, represent… read more here.
Keywords: cytotoxic autophagy; membrane localization; ergosterol; drug ... See more keywords
A Mini Review on Characteristics and Analytical Methods of Otilonium Bromide.
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DOI: 10.1080/10408347.2021.1913983
Abstract: Irritable bowel syndrome (IBS) is a world-wide disease prevalently in Western nations. It influences about 15% of the western populace, with a negative effect on the quality of life and furthermore on medical services costs.… read more here.
Keywords: mini review; review characteristics; analytical methods; otilonium bromide ... See more keywords
Otilonium Bromide: A Drug with a Complex Mechanism of Action.
Sign Up to like & getrecommendations! Published in 2018 at "Current pharmaceutical design"
DOI: 10.2174/1381612824666180507122935
Abstract: Otilonium bromide (OB) is a drug with spasmolytic activity belonging to quaternary ammonium derivatives and extensively used to treat patients affected by the Irritable Bowel Syndrome (IBS). Thanks to its peculiar pharmacokinetic, OB concentrates in… read more here.
Keywords: bromide drug; otilonium bromide; drug; complex mechanism ... See more keywords