Bisphosphonate therapy in otosclerosis: A scoping review
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DOI: 10.1002/lio2.729
Abstract: Otosclerosis, a leading cause of deafness in adults, results from defective bone remodeling of the otic capsule. Bisphosphonates have been used to decrease bone remolding in many diseases, including otosclerosis. This study analyzes whether current… read more here.
Keywords: otosclerosis scoping; otosclerosis; scoping review; therapy otosclerosis ... See more keywords
[Use of the Carina active middle ear implant in otosclerosis patients].
Sign Up to like & getrecommendations! Published in 2021 at "HNO"
DOI: 10.1007/s00106-020-00984-0
Abstract: Patients with otosclerosis can suffer from different grades of combined hearing loss. In addition to surgery (stapedectomy), conventional hearing aids can be used in the treatment of otosclerosis. In cases of severe conductive components in… read more here.
Keywords: middle ear; hearing loss; otosclerosis; otosclerosis patients ... See more keywords
3D fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging at different stages of otosclerosis
Sign Up to like & getrecommendations! Published in 2018 at "European Archives of Oto-Rhino-Laryngology"
DOI: 10.1007/s00405-018-5093-2
Abstract: PurposeThe aim of this work is to study otosclerotic patients by 3D-FLAIR (fluid attenuated inversion recovery) sequence magnetic resonance imaging (MRI) with and without Gadolinium administration (−/+ Gd), to understand whether there is a direct… read more here.
Keywords: attenuated inversion; inversion recovery; flair; otosclerosis ... See more keywords
The effect of female hormone in otosclerosis. A comparative study and speculation about their effect on the ossicular chain based on the clinical results
Sign Up to like & getrecommendations! Published in 2022 at "European Archives of Oto-Rhino-Laryngology"
DOI: 10.1007/s00405-022-07295-w
Abstract: This study aimed at identifying gender differences in the hearing thresholds in a sample of patients with otosclerosis before and after surgery to understand the impact of female hormones on auditory thresholds. This retrospective study… read more here.
Keywords: study; chain; statistically significant; air ... See more keywords
Evidence of distinct RELN and TGFB1 genetic associations in familial and non-familial otosclerosis in a British population
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DOI: 10.1007/s00439-018-1889-9
Abstract: Otosclerosis is a common form of hearing loss which typically presents in young adults. The disease has a familial, monogenic form and a non-familial form with a more complex aetiology. A previous genome wide association… read more here.
Keywords: evidence; association; otosclerosis; tgfb1 ... See more keywords
Does stapes surgery improve tinnitus in patients with otosclerosis?
Sign Up to like & getrecommendations! Published in 2017 at "Brazilian journal of otorhinolaryngology"
DOI: 10.1016/j.bjorl.2016.07.001
Abstract: INTRODUCTION Otosclerosis (OS) is the primary disease of the human temporal bone characterized by conductive hearing loss and tinnitus. The exact pathogenesis of tinnitus in otosclerosis patients is not known and factors affecting the tinnitus… read more here.
Keywords: pitch; pitch tinnitus; otosclerosis; tinnitus ... See more keywords
Otosclerosis: From Genetics to Molecular Biology.
Sign Up to like & getrecommendations! Published in 2018 at "Otolaryngologic clinics of North America"
DOI: 10.1016/j.otc.2017.11.002
Abstract: Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with… read more here.
Keywords: genetics molecular; otosclerosis; biology; molecular biology ... See more keywords
Establishment of an induced pluripotent stem cell line (JTUi003-A) from a patient with otosclerosis.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cell research"
DOI: 10.1016/j.scr.2022.102666
Abstract: Otosclerosis is characterized by abnormal bone remodeling in the osseous labyrinth and progressive hearing loss. Although the etiology of otosclerosis is not fully understood, both environmental and genetic factors play important roles in its pathogenesis.… read more here.
Keywords: otosclerosis; cell line; induced pluripotent; stem cell ... See more keywords
Variants affecting diverse domains of MEPE are associated with two distinct bone disorders, a craniofacial bone defect and otosclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Genetics in Medicine"
DOI: 10.1038/s41436-018-0300-5
Abstract: PurposeTo characterize new molecular factors implicated in a hereditary congenital facial paresis (HCFP) family and otosclerosis.MethodsWe performed exome sequencing in a four-generation family presenting nonprogressive HCFP and mixed hearing loss (HL). MEPE was analyzed using… read more here.
Keywords: variants affecting; family; bone; otosclerosis ... See more keywords
Predictors of hearing outcomes after stapes surgery in otosclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Acta Oto-Laryngologica"
DOI: 10.1080/00016489.2019.1648866
Abstract: Abstract Background: The current surgical treatment of otosclerosis is stapes surgery; however, few studies have reported the predictors of surgical outcomes. Aim/objective: This study aimed to investigate the prognostic predictors for postoperative hearing outcomes. Materials… read more here.
Keywords: postoperative hearing; hearing outcomes; predictors postoperative; stapes surgery ... See more keywords
Frequency-specific hearing results after stapes surgery for Chinese population otosclerosis with different degrees of hearing loss
Sign Up to like & getrecommendations! Published in 2020 at "Acta Oto-Laryngologica"
DOI: 10.1080/00016489.2020.1724331
Abstract: Abstract Background: Frequency-specific hearing studies are important for predicting hearing results and the prognosis after stapes surgery, to prepare for the rehabilitation of frequency-specific hearing in patients with otosclerosis. Objectives: To evaluate outcomes of stapes… read more here.
Keywords: frequency specific; hearing loss; frequency; stapes surgery ... See more keywords